Itoh T, Kagiyama N
Central Institute for Experimental Animals, Kanagawa, Japan.
Jikken Dobutsu. 1990 Jul;39(3):425-8. doi: 10.1538/expanim1978.39.3_425.
The median liver lesion producing doses of peroral inoculation with the spores of Tyzzer's organism RJ strain were 10(4. 3) in rats and 10(2. 7) in rats receiving prednisolone treatment for the provocation of Tyzzer's disease. In contrast to rats, liver lesions were detected in few mice inoculated perorally with 10(7) spores. In mice inoculated perorally with 10(7) spores, excretion of infective spores in the feces was detected only on day 1 postinoculation. On the other hand, no difference in susceptibility between rats and mice was detected upon intravenous inoculation with vegetative cells of the RJ strain. These results suggest that germination of the spores in the intestinal tract causes the difference in the susceptibility in rats and mice.
经口接种泰泽氏病原体RJ株孢子后，大鼠肝脏产生病变的半数剂量为10(4. 3) ，而接受泼尼松龙治疗以诱发泰泽氏病的大鼠肝脏产生病变的半数剂量为10(2. 7) 。与大鼠不同，经口接种10(7) 个孢子的小鼠中很少检测到肝脏病变。在经口接种10(7) 个孢子的小鼠中，仅在接种后第1天检测到粪便中有感染性孢子排出。另一方面，静脉接种RJ株营养细胞后，未检测到大鼠和小鼠在易感性上的差异。这些结果表明，孢子在肠道中的萌发导致了大鼠和小鼠在易感性上的差异。
