Waggie K S, Thornburg L P, Wagner J E
Lab Anim Sci. 1986 Oct;36(5):492-5.
Tyzzer's disease was induced experimentally in nonimmunosuppressed, weanling Mystromys albicaudatus by oral inoculation with Bacillus piliformis spores. Focal areas of necrosis bordered by cells containing B. piliformis were observed first in the tunica muscularis of the intestine and in the periportal region of the liver 3 days post-inoculation, in the ventricular myocardium 7 days post-inoculation and in the brainstem 9 days post-inoculation. Healing in the tunica muscularis, liver and myocardium was accompanied by granuloma formation. The findings indicate that Mystromys are susceptible to B. piliformis infection. This is, to our knowledge, the first time brain lesions have been reported in any species following oral inoculation with B. piliformis. Tyzzer's disease should be considered as a possible diagnosis in Mystromys with hepatoenteritis, myocarditis, or indications of central nervous system disorders.
通过给未免疫抑制的断奶小白鼠经口接种丝状芽孢杆菌孢子，实验性诱导其患泰泽氏病。接种后3天，在肠道肌层和肝脏门周区域首先观察到以含有丝状芽孢杆菌的细胞为边界的局灶性坏死区域；接种后7天，在心室心肌中观察到；接种后9天，在脑干中观察到。肌层、肝脏和心肌的愈合伴随着肉芽肿形成。这些发现表明小白鼠对丝状芽孢杆菌感染易感。据我们所知，这是首次报道在经口接种丝状芽孢杆菌后任何物种出现脑部病变。对于患有肝炎、肠炎、心肌炎或有中枢神经系统疾病迹象的小白鼠，应考虑将泰泽氏病作为一种可能的诊断。
