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脊髓栓系综合征的尿动力学研究

Urodynamic studies in spinal cord tethering.

作者信息

Kearns James T, Esposito Domenic, Dooley Beverly, Frim David, Gundeti Mohan S

机构信息

Comer Children's Hospital, The University of Chicago Medicine & Biological Sciences, IL 60637, USA.

出版信息

Childs Nerv Syst. 2013 Sep;29(9):1589-600. doi: 10.1007/s00381-013-2136-2. Epub 2013 Sep 7.

DOI:10.1007/s00381-013-2136-2
PMID:24013329
Abstract

INTRODUCTION

Tethered cord syndrome (TCS) is of particular interest to urologists through its effects on the function of the lower urinary tract. Tethering of the spinal cord can result in bladder dysfunction with multiple manifestations, clinically raging from urinary retention and detrusor under-activity to urinary incontinence, over-activity of the detrusor, and sphincter dysfunction. Goals of management include protecting renal function and preserving patient quality of life.

METHODS

Evaluation of a TCS patient with urinary complaints begins with a thorough history and physical examination. Further characterization of urinary symptoms with a voiding diary provides vital information that helps to direct treatment while engaging the patient and family in the treatment plan. Urodynamic studies then provide key diagnostic data regarding bladder function, bladder outlet resistance, and urinary sphincter function. In the pediatric population, particular care must be paid to counseling patients and their families prior to the procedure to alleviate the often-considerable anxiety associated with an invasive procedure.

CONCLUSION

The armamentarium for management of neurogenic bladder associated with TCS includes behavioral training, biofeedback therapy, medications, patient-performed procedures, and surgical intervention. The choice of intervention depends on the patient's symptoms, urodynamic findings, and patient and family preferences. The primary problem of TCS should be addressed first through detethering, and then the urological team can use progressively more aggressive therapies as necessary. Interpretation and treatment by a dedicated, specialized, multidisciplinary team that includes the pediatric urologist, pediatric neurosurgeon and dedicated nurse practitioner, is critical for successful treatment.

摘要

引言

脊髓拴系综合征(TCS)因其对下尿路功能的影响而备受泌尿科医生关注。脊髓拴系可导致膀胱功能障碍,表现多样,临床上从尿潴留、逼尿肌活动低下到尿失禁、逼尿肌过度活动及括约肌功能障碍。治疗目标包括保护肾功能和维持患者生活质量。

方法

对有泌尿系统症状的TCS患者进行评估,首先要进行全面的病史询问和体格检查。通过排尿日记进一步描述泌尿系统症状,可提供重要信息,有助于指导治疗,同时让患者及其家属参与治疗计划。尿动力学研究则可提供有关膀胱功能、膀胱出口阻力及尿道括约肌功能的关键诊断数据。在儿科患者中,在进行该检查前,必须特别注意向患者及其家属提供咨询,以减轻与侵入性检查相关的常见的严重焦虑。

结论

治疗与TCS相关的神经源性膀胱的方法包括行为训练、生物反馈疗法、药物治疗、患者自行操作的治疗方法及手术干预。干预方法的选择取决于患者的症状、尿动力学检查结果以及患者和家属的偏好。TCS的主要问题应首先通过解除拴系来解决,然后泌尿科团队可根据需要逐步采用更积极的治疗方法。由包括小儿泌尿科医生、小儿神经外科医生和专业护士在内的专业多学科团队进行解读和治疗,对成功治疗至关重要。

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BJU Int. 2013 Nov;112(7):1009-17. doi: 10.1111/bju.12289.
2
Randomized double-blind, active-controlled phase 3 study to assess 12-month safety and efficacy of mirabegron, a β(3)-adrenoceptor agonist, in overactive bladder.米拉贝隆治疗膀胱过度活动症的随机、双盲、阳性药物对照 3 期临床试验:12 个月安全性和疗效评估
Eur Urol. 2013 Feb;63(2):296-305. doi: 10.1016/j.eururo.2012.10.048. Epub 2012 Nov 6.
3
Robotic paediatric urology.
脊髓栓系综合征的诊断与治疗。
Adv Tech Stand Neurosurg. 2024;49:35-50. doi: 10.1007/978-3-031-42398-7_3.
4
Gastrulation and Split Cord Malformation.原肠胚形成和脊髓分裂畸形。
Adv Tech Stand Neurosurg. 2023;47:1-23. doi: 10.1007/978-3-031-34981-2_1.
5
Effects of electroacupuncture on pediatric chronic urinary retention: a case-series study.电针对小儿慢性尿潴留的影响:一项病例系列研究。
Front Pediatr. 2023 Jul 21;11:1194651. doi: 10.3389/fped.2023.1194651. eCollection 2023.
6
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Pediatr Surg Int. 2022 Oct;38(10):1487-1494. doi: 10.1007/s00383-022-05186-z. Epub 2022 Jul 26.
8
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9
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Curr Urol Rep. 2015 Nov;16(11):78. doi: 10.1007/s11934-015-0550-6.
机器人小儿外科学。
BJU Int. 2012 Jul;110(1):2-13. doi: 10.1111/j.1464-410X.2011.10877.x. Epub 2012 Mar 19.
4
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5
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J Urol. 2009 Apr;181(4):1862-7; discussion 1867-8. doi: 10.1016/j.juro.2008.12.001. Epub 2009 Feb 23.
10
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Eur Urol. 2008 Dec;54(6):1287-96. doi: 10.1016/j.eururo.2008.01.076. Epub 2008 Feb 8.