Ziliotto G, Lamberti G
Minerva Med. 1975 Sep 5;66(57):2823-34.
The antiarthrosic effectiveness with respect to spontaneous pain upon movement and pressure, of alclofenac (4-allyloxy-3-chlorophenyl-acetic acid) was tested in a homogeneous group of elderly patients and compared with orally administered indomethacin. The research was carried out in strictly controlled, double-blind experimental conditions. The results obtained suggest that 500 mg of the new anti-inflammatory analgesic have the same action as 25 mg of indomethacin but with a lower incidence of the side effects common to all anti-inflammatory substances. Thanks to its good tolerability and high effectiveness, the new drug should be of considerable utility in the treatment of arthrosis in the elderly and in painful, inflammatory complications.
在一组老年患者中测试了阿氯芬酸（4-烯丙氧基-3-氯苯基乙酸）对运动和压力引发的自发疼痛的抗关节炎效果，并与口服吲哚美辛进行了比较。该研究在严格控制的双盲实验条件下进行。所得结果表明，500毫克这种新型抗炎镇痛药与25毫克吲哚美辛具有相同的作用，但所有抗炎物质常见的副作用发生率较低。由于其良好的耐受性和高效性，这种新药在治疗老年人的关节炎以及疼痛性炎症并发症方面应具有相当大的效用。
