Cai Xiang, Yang Lie, Chen Haining, Wang Cun
Department of Urology, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, People's Republic of China.
Tumour Biol. 2014 Feb;35(2):949-53. doi: 10.1007/s13277-013-1125-0. Epub 2013 Sep 8.
Glutathione S-transferases (GSTs) are a large family of phase II detoxification enzymes that are expressed in many tissues and play critical roles in protecting hosts against cancer. The association of glutathione S-transferase M1 (GSTM1) polymorphism with susceptibility to colorectal cancer in Asians has not been well established. We performed a meta-analysis to quantitatively assess the association between GSTM1 polymorphism and colorectal cancer in Asians. We systematically searched the PubMed and Embase databases to identify the eligible studies. Finally, 17 eligible studies with 5,907 cases and 9,726 controls were included into the meta-analysis. The pooled odds ratio (OR) with its 95 % confidence intervals (95 %CI) was used to assess the association. The meta-analysis of those included studies suggests that GSTM1 null genotype was significantly associated with colorectal cancer risk in Asians (OR = 1.14, 95 %CI = 1.013-1.29, P = 0.03). The cumulative meta-analyses showed a trend of an obvious association between the GSTM1 null genotype and risk of colorectal cancer in Asians as information accumulated by year. Thus, there is an obvious association between the GSTM1 null genotype and risk of colorectal cancer in Asians.
谷胱甘肽S-转移酶（GSTs）是一大类II期解毒酶，在许多组织中表达，在保护宿主免受癌症侵害方面发挥着关键作用。谷胱甘肽S-转移酶M1（GSTM1）基因多态性与亚洲人患结直肠癌易感性之间的关联尚未明确确立。我们进行了一项荟萃分析，以定量评估亚洲人中GSTM1基因多态性与结直肠癌之间的关联。我们系统检索了PubMed和Embase数据库以确定符合条件的研究。最终，17项符合条件的研究（包括5907例病例和9726例对照）被纳入荟萃分析。采用合并比值比（OR）及其95%置信区间（95%CI）来评估这种关联。对纳入研究的荟萃分析表明，GSTM1基因缺失型与亚洲人患结直肠癌风险显著相关（OR = 1.14，95%CI = 1.013 - 1.29，P = 0.03）。累积荟萃分析显示，随着逐年积累信息，GSTM1基因缺失型与亚洲人患结直肠癌风险之间存在明显关联趋势。因此，GSTM1基因缺失型与亚洲人患结直肠癌风险之间存在明显关联。
