Abou-Khadra Maha K, Kishk Nirmeen A, Shaker Olfat G, Hassan Amr
Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt
Department of Neurology, Faculty of Medicine, Cairo University, Egypt.
J Child Neurol. 2014 Jul;29(7):947-51. doi: 10.1177/0883073813502394. Epub 2013 Sep 5.
We conducted the present study to assess melatonin secretion in a sample of children with migraine, to describe their sleep patterns and problems, and to examine the impact of sleep problems on migraine disability. The parents of 18 children with migraine completed the Children's Sleep Habits Questionnaire and Pediatric Migraine Disability Assessment Score in Arabic. The parents of 18 healthy controls also completed the Children's Sleep Habits Questionnaire. Urinary 6-sulphatoxymelatonin levels were determined with the enzyme-linked immunosorbent assay method. There was no significant difference in urinary 6-sulphatoxymelatonin between the migraine and control groups (Z = -0.127, P = .889). There were no significant differences between groups in Children's Sleep Habits Questionnaire subscales or total scores. There were significant correlations between bedtime resistance, parasomnias subscales, and migraine disability. Our findings indicate that nocturnal production of melatonin is not reduced in children with migraine, and sleep disturbances impact the degree of migraine disability.
我们开展了本研究，以评估偏头痛患儿样本中的褪黑素分泌情况，描述他们的睡眠模式及问题，并研究睡眠问题对偏头痛致残程度的影响。18名偏头痛患儿的家长用阿拉伯语填写了《儿童睡眠习惯问卷》和《儿童偏头痛致残评估量表》。18名健康对照儿童的家长也填写了《儿童睡眠习惯问卷》。采用酶联免疫吸附测定法测定尿6-硫酸氧基褪黑素水平。偏头痛组和对照组的尿6-硫酸氧基褪黑素水平无显著差异（Z = -0.127，P = .889）。两组在《儿童睡眠习惯问卷》各子量表或总分上无显著差异。就寝抗拒、异态睡眠子量表与偏头痛致残程度之间存在显著相关性。我们的研究结果表明，偏头痛患儿夜间褪黑素分泌并未减少，睡眠障碍会影响偏头痛的致残程度。
