Al-Omran Ammar K, Sadat-Ali Mir
Department of Orthopaedic Surgery, College of Medicine, University of Dammam, King Fahd Hospital of the University, Al-Khobar, Saudi Arabia.
J Orthop Surg (Hong Kong). 2013 Aug;21(2):258-61. doi: 10.1177/230949901302100230.
Legg-Calve-Perthes disease (LCPD) is a type of avascular necrosis of the femoral head occurring mainly in male children and causing early osteoarthritis. We report 2 generations of 4 male family members with LCPD-like features and mutation of the COL2A1 gene of the 12q13 chromosome. If LCPD occurs in any family member, we recommend genetic analysis and counselling as well as early radiological screening of related children.
Legg-Calve-Perthes病（LCPD）是一种主要发生于男性儿童的股骨头缺血性坏死，可导致早期骨关节炎。我们报告了两代共4名具有LCPD样特征且12q13染色体上COL2A1基因发生突变的男性家庭成员。如果任何家庭成员发生LCPD，我们建议进行基因分析和咨询，并对相关儿童进行早期影像学筛查。
