伊朗儿童中内皮型一氧化氮合酶27碱基对可变数目串联重复序列、894G>T和786T>C多态性与Legg-Calve-Perthes病易感性的关联。
Association of eNOS 27-bp VNTR, 894G>T and 786T>C polymorphisms with susceptibility to Legg-Calve-Perthes Disease in Iranian children.
作者信息
Azarpira Mohammad Reza, Ghilian Mohammad Mahdi, Sobhan Mohammad Reza, Mahdinezhad-Yazdi Masoud, Aghili Kazem, Ahrar Hossein, Neamatzadeh Hossein
机构信息
Bone and Joint Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
出版信息
J Orthop. 2019 Feb 26;16(2):137-140. doi: 10.1016/j.jor.2019.02.024. eCollection 2019 Mar-Apr.
Abstract
BACKGROUND
The aim of this study was to analyze the association of eNOS polymorphisms with risk of Legg-Calve-Perthes Disease (LCPD).
METHODS
The study comprised of 45 LCPD patients and 55 controls. The eNOS polymorphisms were genotyped with PCR and by PCR-RFLP.
RESULTS
The eNOS 894G > T and -786T > C polymorphisms were significantly associated with an increased risk of LCPD. However, there was no significant association between eNOS 27-bp VNTR polymorphism and LCPD risk.
CONCLUSION
Our results suggest that the eNOS 894G > T and -786T > C polymorphisms may be a risk factor for LCPD in Iranian children, but not 27-bp VNTR polymorphism.
摘要
背景
本研究旨在分析内皮型一氧化氮合酶（eNOS）基因多态性与Legg-Calve-Perthes病（LCPD）风险之间的关联。
方法
该研究纳入了45例LCPD患者和55例对照。采用聚合酶链反应（PCR）及PCR-限制性片段长度多态性分析（PCR-RFLP）对eNOS基因多态性进行基因分型。
结果
eNOS 894G>T和-786T>C基因多态性与LCPD风险增加显著相关。然而，eNOS 27bp可变数目串联重复序列（VNTR）多态性与LCPD风险之间无显著关联。
结论
我们的结果表明，eNOS 894G>T和-786T>C基因多态性可能是伊朗儿童患LCPD的一个风险因素，但27bp VNTR多态性并非如此。
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