Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
PLoS One. 2013 Aug 28;8(8):e70961. doi: 10.1371/journal.pone.0070961. eCollection 2013.
HIF-1α is a major regulator in tumor progression and metastasis which responds to hypoxia. Many studies have demonstrated that hypoxia-inducible factor1-α (HIF-1α) polymorphisms are significantly associated with cancer metastasis, but the results are inconsistent. We conducted a comprehensive meta-analysis to estimate the associations between HIF-1α C1772 T polymorphism and cancer metastasis.
Comprehensive searches were conducted on PubMed and EMBASE database. Fifteen studies were included in the meta-analysis. We used the OR and 95%CI to assess the associations between HIF-1α C1772T polymorphism and cancer metastasis. Heterogeneity and publication bias were also assessed by Q test, I (2), and funnel plot.
Totally, fifteen studies including 1239 cases with metastasis-positive (M+) and 2711 cases with metastasis-negative (M-) were performed in this meta-analysis. The results showed that HIF-1a C1772T polymorphism was associated with the increased risk of cancer metastasis (T allele vs. C allele, OR = 1.36, 95% CI = 1.12-1.64; TT+ TC vs. CC, OR = 1.39, 95% CI = 1.13-1.71; TT vs. TC+ CC, OR = 1.93, 95% CI = 0.86-4.36). In the subgroup analyses, the significant associations remained significant among Asians, Caucasians and other cancers in the dominant model. Publication bias was not observed in the analysis.
Our results indicate that the HIF-1αC1772T polymorphism T allele may increase the risk of cancer metastasis, which might be a potential risk factor of cancer progress.
HIF-1α 是肿瘤进展和转移的主要调节因子，对缺氧有反应。许多研究表明，缺氧诱导因子 1-α（HIF-1α）多态性与癌症转移显著相关，但结果不一致。我们进行了一项综合荟萃分析，以评估 HIF-1α C1772T 多态性与癌症转移之间的关系。
在 PubMed 和 EMBASE 数据库中进行了全面检索。有 15 项研究纳入荟萃分析。我们使用 OR 和 95%CI 来评估 HIF-1α C1772T 多态性与癌症转移之间的关系。还通过 Q 检验、I（2）和漏斗图评估了异质性和发表偏倚。
共有 15 项研究（包括 1239 例转移阳性（M+）和 2711 例转移阴性（M-））纳入本荟萃分析。结果表明，HIF-1a C1772T 多态性与癌症转移的风险增加相关（T 等位基因与 C 等位基因相比，OR = 1.36，95%CI = 1.12-1.64；TT+TC 与 CC 相比，OR = 1.39，95%CI = 1.13-1.71；TT 与 TC+CC 相比，OR = 1.93，95%CI = 0.86-4.36）。在亚组分析中，显性模型中亚洲人、白种人和其他癌症的相关性仍然显著。分析中未发现发表偏倚。
我们的结果表明，HIF-1α C1772T 多态性 T 等位基因可能会增加癌症转移的风险，这可能是癌症进展的潜在危险因素。
