麻醉剂对癌症复发和转移的影响及其临床意义。
The Effects of Anesthetics on Recurrence and Metastasis of Cancer, and Clinical Implications.
作者信息
Yang Wenjing, Cai Jun, Zabkiewicz Catherine, Zhang Huiming, Ruge Fiona, Jiang Wen G
机构信息
Department of Anesthesiology, Beijing Tong Ren Hospital, Capital Medical University, Dong-Cheng, Beijing 100065, China.
Cardiff China Medical Research Collaborative, Division of Cancer and Genetics, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.
出版信息
World J Oncol. 2017 Jun;8(3):63-70. doi: 10.14740/wjon1031e. Epub 2017 Jun 9.
Abstract
Surgical resection of the primary tumor may enhance the metastasis and recurrence of cancer. The reaction of patients to surgery includes changes of the immune system, the inflammatory system and the neuroendocrine system. In the perioperative period, anesthetics are used both for anesthesia and analgesia. There are several studies showing that the progression of cancer can be influenced by many kinds of anesthetics, although most of these studies are preclinical and thus have not yet influenced clinical recommendations. This review summarizes recent studies regarding the effects of anesthetics on metastasis and recurrence of cancer.
摘要
原发性肿瘤的手术切除可能会促进癌症的转移和复发。患者对手术的反应包括免疫系统、炎症系统和神经内分泌系统的变化。在围手术期，麻醉剂用于麻醉和镇痛。有多项研究表明，多种麻醉剂可影响癌症的进展，尽管这些研究大多处于临床前阶段，因此尚未影响临床建议。本综述总结了关于麻醉剂对癌症转移和复发影响的近期研究。
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本文引用的文献
1
Lidocaine Induces Apoptosis and Suppresses Tumor Growth in Human Hepatocellular Carcinoma Cells In Vitro and in a Xenograft Model In Vivo.
Anesthesiology. 2017 May;126(5):868-881. doi: 10.1097/ALN.0000000000001528.
2
Effects of etomidate and propofol on immune function in patients with lung adenocarcinoma.
Am J Transl Res. 2016 Dec 15;8(12):5748-5755. eCollection 2016.
3
Effects of propofol and sevoflurane on perioperative immune response in patients undergoing laparoscopic radical hysterectomy for cervical cancer.
Medicine (Baltimore). 2016 Dec;95(49):e5479. doi: 10.1097/MD.0000000000005479.
4
Reversal effects of local anesthetics on P-glycoprotein-mediated cancer multidrug resistance.
Anticancer Drugs. 2017 Mar;28(3):243-249. doi: 10.1097/CAD.0000000000000455.
5
Sevoflurane attenuates platelets activation of patients undergoing lung cancer surgery and suppresses platelets-induced invasion of lung cancer cells.
J Clin Anesth. 2016 Dec;35:304-312. doi: 10.1016/j.jclinane.2016.08.008. Epub 2016 Oct 12.
6
Amide-linked local anesthetics induce apoptosis in human non-small cell lung cancer.
J Thorac Dis. 2016 Oct;8(10):2748-2757. doi: 10.21037/jtd.2016.09.66.
7
Morphine enhances renal cell carcinoma aggressiveness through promotes survivin level.
Ren Fail. 2017 Nov;39(1):258-264. doi: 10.1080/0886022X.2016.1256322. Epub 2016 Nov 21.
8
Sevoflurane inhibits the migration and invasion of glioma cells by upregulating microRNA-637.
Int J Mol Med. 2016 Dec;38(6):1857-1863. doi: 10.3892/ijmm.2016.2797. Epub 2016 Nov 8.
9
Propofol inhibits growth and invasion of pancreatic cancer cells through regulation of the miR-21/Slug signaling pathway.
Am J Transl Res. 2016 Oct 15;8(10):4120-4133. eCollection 2016.
10
Differential role of intravenous anesthetics in colorectal cancer progression: implications for clinical application.
Oncotarget. 2016 Nov 22;7(47):77087-77095. doi: 10.18632/oncotarget.12800.
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