Circulation. 2013 Oct 8;128(15):1689-712. doi: 10.1161/CIR.0b013e3182a5cfb3. Epub 2013 Sep 9.
Severe obesity afflicts between 4% and 6% of all youth in the United States, and the prevalence is increasing. Despite the serious immediate and long-term cardiovascular, metabolic, and other health consequences of severe pediatric obesity, current treatments are limited in effectiveness and lack widespread availability. Lifestyle modification/behavior-based treatment interventions in youth with severe obesity have demonstrated modest improvement in body mass index status, but participants have generally remained severely obese and often regained weight after the conclusion of the treatment programs. The role of medical management is minimal, because only 1 medication is currently approved for the treatment of obesity in adolescents. Bariatric surgery has generally been effective in reducing body mass index and improving cardiovascular and metabolic risk factors; however, reports of long-term outcomes are few, many youth with severe obesity do not qualify for surgery, and access is limited by lack of insurance coverage. To begin to address these challenges, the purposes of this scientific statement are to (1) provide justification for and recommend a standardized definition of severe obesity in children and adolescents; (2) raise awareness of this serious and growing problem by summarizing the current literature in this area in terms of the epidemiology and trends, associated health risks (immediate and long-term), and challenges and shortcomings of currently available treatment options; and (3) highlight areas in need of future research. Innovative behavior-based treatment, minimally invasive procedures, and medications currently under development all need to be evaluated for their efficacy and safety in this group of patients with high medical and psychosocial risks.
在美国,严重肥胖影响着 4%至 6%的所有青少年,且其发病率还在不断上升。尽管严重的儿科肥胖症会立即产生严重的心血管、代谢和其他健康后果,且其长期影响也不容小觑,但目前的治疗方法效果有限,且无法广泛普及。针对严重肥胖青少年的生活方式改变/基于行为的治疗干预已证明可适度改善体重指数状况,但参与者通常仍处于严重肥胖状态,且在治疗计划结束后往往会体重反弹。医学管理的作用有限,因为目前仅有 1 种药物被批准用于治疗青少年肥胖症。减肥手术通常可有效降低体重指数并改善心血管和代谢风险因素;然而,长期结果的报告很少,许多严重肥胖的青少年不符合手术条件,且由于缺乏保险覆盖,手术机会有限。为了开始应对这些挑战,本科学声明的目的是:(1)为儿童和青少年严重肥胖症提供合理化定义并建议采用标准化定义;(2)通过总结该领域的现有文献,从流行病学和趋势、相关健康风险(即立即和长期)以及现有治疗方案的挑战和局限性方面,提高对这一严重且日益严重的问题的认识;(3)突出需要未来研究的领域。创新的基于行为的治疗、微创程序和正在开发的药物都需要在这群具有高医疗和心理社会风险的患者中评估其疗效和安全性。