Zhang Qing, Hu Juan, Xu Xin-da, Chen Yan-fei, Zhang Yan, Wei Jun-rong, Zhang Quan-an, Xu Min, Kimitaka Kaga
Department of Otorhinolaryngology Head and Neck Surgery, Xi'an Jiaotong University College of Medicine, Xi'an, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 May;48(5):389-93.
To observe the function of the otolithic end organs and their input pathways in sudden sensorineural hearing loss (SSHL) patients.
Forty cases of unilateral SSHL were enrolled as the observing group from May, 2011 to May, 2012. Thirty age- and gender-matched normal subjects were recruited as the control group. Both patients and normal subjects underwent conventional air-conducted ocular vestibular evoked myogenic potential (oVEMP) and cervical vestibular evoked myogenic potential (cVEMP) in bilateral ears. The results were compared between the affected ears, the contralateral ears and the normal controls.
Overall, oVEMP was elicited in 16 affected ears (40.0%), 23 contralateral ears (57.5%) and 43 normal ears (71.7%). cVEMP could be elicited in 25 affected ears (62.5%), 30 contralateral ears (75.0%) and 49 normal ears (81.7%) respectively. Significant statistical significance could be found in the oVEMP response rate between the affected ears and the normal ears (χ(2) = 9.949, P = 0.002) and in the cVEMP response rate between the affected ears and the normal ears (χ(2) = 4.582, P = 0.032). Significant statistical difference could not be found in all oVEMP and cVEMP parameters (threshold, N1 latency, P1 latency, latency interval and amplitude) among groups (P > 0.05).
The otolithic vestibular end organs and their input pathways could be damaged in SSHL patients. Such damages could be monitored objectively by cVEMP and oVEMP examinations.
观察突发性感音神经性听力损失（SSHL）患者耳石终器及其传入通路的功能。
选取2011年5月至2012年5月期间收治的40例单侧SSHL患者作为观察组。选取30例年龄、性别匹配的正常受试者作为对照组。所有患者及正常受试者均接受双耳常规气导眼震前庭诱发肌源性电位（oVEMP）和颈前庭诱发肌源性电位（cVEMP）检查。比较患耳、对侧耳及正常对照耳的检查结果。
总体而言，患耳中16耳（40.0%）引出oVEMP，对侧耳中23耳（57.5%）引出oVEMP，正常耳中43耳（71.7%）引出oVEMP。患耳中25耳（62.5%）引出cVEMP，对侧耳中30耳（75.0%）引出cVEMP，正常耳中49耳（81.7%）引出cVEMP。患耳与正常耳之间oVEMP引出率差异有统计学意义（χ(2)=9.949，P=0.002），患耳与正常耳之间cVEMP引出率差异有统计学意义（χ(2)=4.582，P=0.032）。各组间所有oVEMP和cVEMP参数（阈值、N1潜伏期、P1潜伏期、潜伏期间期及波幅）差异均无统计学意义（P>0.05）。
SSHL患者的耳石前庭终器及其传入通路可能受损。可通过cVEMP和oVEMP检查客观监测此类损伤。
