Zhang Qing, Xu Xinda, Niu Xiaorong, Hu Juan, Chen Yanfei, Xu Min
Department of Otorhinolaryngology, Head and Neck Surgery, Second Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an 710004, China.
Department of Otorhinolaryngology, Head and Neck Surgery, Second Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an 710004, China. Email:
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Nov;49(11):897-901.
To identify the aging effects on air-conducted sound (ACS) elicited ocular vestibular-evoked myogenic potential (oVEMP) and cervical vestibular-evoked myogenic potential (cVEMP) in normal Chinese population.
Nighty-seven normal subjects (194 ears) were recruited for conventional ACS-oVEMP and ACS-cVEMP examinations. The candidates'age were 4-83 years old (Ave. ± SD, 45.7 ± 19.3), 41 male and 56 female, divided into 5 groups according to age. 500 Hz short tone burst was employed for examinations. Thresholds were identified and the parameters of the responses to 100dB nHL were calculated and compared among groups. SPSS 13.0 software was used to analyze the date.
As the age growing, the response rate for oVEMP decreased. It was recorded 100% in both ≤ 10-year-old and 11-30-year-old groups, 84.00% in the 31-50-year-old group, 48.15% in the 51-70-year-old group and 15.00% in the > 70-year-old group; while that for cVEMP were 100% in both ≤ 10-year-old group and 11-30-year-old group, 82.00% in the 31-50-year-old group, 77.78% in the 51-70-year-old group and 45.00% in the > 70-year-old group. The thresholds elevated and the amplitudes decreased in both examinations with the age growing. However, latencies and latency-intervals of both oVEMP and cVEMP examinations displayed minor difference among groups except that nI latency of oVEMP prolonged with age growing.
With the age growing, the otolithic end organ input pathways degenerate in normal subjects, as shown that ACS elicited oVEMP and cVEMP responsed less with higher threshold and smaller amplitude. The extremely low response rates of both VEMPs in the > 70-year-old group in this study indicates that VEMPs can only provide limited diagnostic information among very old people in clinical practice.
确定年龄增长对正常中国人群中空气传导声音（ACS）诱发的眼前庭诱发肌源性电位（oVEMP）和颈前庭诱发肌源性电位（cVEMP）的影响。
招募97名正常受试者（194耳）进行常规ACS-oVEMP和ACS-cVEMP检查。受试者年龄为4至83岁（平均±标准差，45.7±19.3），男性41名，女性56名，按年龄分为5组。采用500Hz短纯音进行检查。确定阈值，并计算和比较各组对100dB nHL反应的参数。使用SPSS 13.0软件分析数据。
随着年龄增长，oVEMP的反应率下降。≤10岁组和11至30岁组的记录率均为100%，31至50岁组为84.00%，51至70岁组为48.15%，>70岁组为15.00%；而cVEMP在≤10岁组和11至30岁组均为100%，31至50岁组为82.00%，51至70岁组为77.78%，>70岁组为45.00%。随着年龄增长，两项检查的阈值均升高，幅度均降低。然而，除了oVEMP的nI潜伏期随年龄增长而延长外，oVEMP和cVEMP检查的潜伏期和潜伏期间隔在各组之间显示出微小差异。
随着年龄增长，正常受试者的耳石终器输入通路退化，表现为ACS诱发的oVEMP和cVEMP反应减少，阈值升高，幅度减小。本研究中>70岁组两种VEMP的极低反应率表明，在临床实践中，VEMP在老年人中只能提供有限的诊断信息。
