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天然木脂素 Hydnocarpin 的抗增殖活性与结肠癌 Wnt/β-连环蛋白信号通路的抑制有关。

Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells.

机构信息

College of Pharmacy, Natural Products Research Institute, Seoul National University, San 56-1 Sillim-dong, Gwanak-gu, Seoul 151-741, Republic of Korea.

出版信息

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5511-4. doi: 10.1016/j.bmcl.2013.08.065. Epub 2013 Aug 22.

DOI:10.1016/j.bmcl.2013.08.065
PMID:24018191
Abstract

Based on the Wnt inhibitors as potential targets in the development of anticancer agents, natural compounds were evaluated for β-catenin-mediated transcriptional activity. A natural lignan hydnocarpin isolated from Lonicera japonica was considered a potential inhibitor for Wnt/β-catenin signalings. The anti-proliferative activity of hydnocarpin was also found to be associated with the suppression of Wnt/β-catenin-mediated signaling pathway in human colon cancer cells. These data suggest that hydnocarpin might be a novel Wnt inhibitor and has a potential of signaling regulator in β-catenin-mediated signaling pathways.

摘要

基于 Wnt 抑制剂作为抗癌药物开发的潜在靶点，评估了天然化合物对β-连环蛋白介导的转录活性的影响。从忍冬属植物中分离得到的天然木脂素氢化卡品被认为是 Wnt/β-连环蛋白信号通路的潜在抑制剂。氢化卡品的抗增殖活性也与抑制人结肠癌细胞中的 Wnt/β-连环蛋白介导的信号通路有关。这些数据表明，氢化卡品可能是一种新型的 Wnt 抑制剂，并且在β-连环蛋白介导的信号通路中具有作为信号调节剂的潜力。

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