Hummer Alfred A, Rompel Annette
Institut für Biophysikalische Chemie, Universität Wien, Wien, Austria.
Adv Protein Chem Struct Biol. 2013;93:257-305. doi: 10.1016/B978-0-12-416596-0.00008-7.
This review gives a brief description of the theory and application of X-ray absorption spectroscopy (XAS) comprising both X-ray absorption near-edge structure and extended X-ray absorption fine structure, especially focusing onto the use in inorganic medicinal chemistry. The advantages and limitations of the methods are described and showcased through examples from studies on anticancer metal compounds. The strength of XAS and its relevance for the structural chemical characterization of metal-based compounds in vivo in native tissue samples is exemplified. The common data reduction and analysis strategies are presented and recent advances in the field and perspectives for the near future are given.
本综述简要描述了X射线吸收光谱法（XAS）的理论与应用，该方法包括X射线吸收近边结构和扩展X射线吸收精细结构，尤其着重于其在无机药物化学中的应用。通过抗癌金属化合物研究中的实例，描述并展示了这些方法的优点和局限性。举例说明了XAS的优势及其在天然组织样品中对体内金属基化合物进行结构化学表征的相关性。介绍了常见的数据处理和分析策略，并给出了该领域的最新进展以及对不久将来的展望。
