Lee H H, Hill G M, Sikha V K, Brewer G J, Prasad A S, Owyang C
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor.
J Lab Clin Med. 1990 Sep;116(3):283-8.
The objectives of this study were (1) to examine basal and cholecystokinin-stimulated pancreaticobiliary secretion of zinc in normal subjects with zinc-adequate and zinc-deficient diets, and (2) to investigate whether basal and stimulated secretion of zinc was abnormal in patients with Wilson's disease before and after zinc therapy. Gastroduodenal intubation was performed in six healthy subjects and five patients with Wilson's disease. After intravenous infusion of octapeptide of cholecystokinin (40 ng/kg/hr) the pancreaticobiliary secretion of zinc increased from a basal rate of 283.1 +/- 75.8 nmol/L/min to a peak of 716.6 +/- 175.3 nmol/L/min in normal subjects. Normal subjects with a zinc-deficient diet had both lower basal (66.8 +/- 15.8 nmol/L/min) and stimulated (559.5 +/- 31 nmol/L/min) pancreaticobiliary secretion of zinc than with a zinc-sufficient diet. In contrast to the markedly reduced pancreaticobiliary secretion of copper, patients with Wilson's disease not treated with zinc had normal basal (226.6 +/- 126 nmol/L/min) and stimulated (728.7 +/- 195.5 nmol/L/min) zinc secretion. These studies indicate that a considerable amount of zinc is being secreted in pancreaticobiliary fluid in healthy subjects and there was no impairment of zinc secretion in patients with Wilson's disease. Our data also indicate that pancreaticobiliary secretion of zinc is dependent on the zinc status of the subjects, suggesting that endogenous secretion of zinc may play a significant role in the homeostasis of zinc.
（1）在饮食锌充足和锌缺乏的正常受试者中，检测基础状态下以及胆囊收缩素刺激后的胰胆锌分泌；（2）调查威尔逊病患者在锌治疗前后基础状态下以及刺激后的锌分泌是否异常。对6名健康受试者和5名威尔逊病患者进行了胃十二指肠插管。静脉输注胆囊收缩素八肽（40 ng/kg/小时）后，正常受试者胰胆锌分泌从基础速率283.1±75.8 nmol/L/分钟增加到峰值716.6±175.3 nmol/L/分钟。饮食锌缺乏的正常受试者基础状态下（66.8±15.8 nmol/L/分钟）和刺激后（559.5±31 nmol/L/分钟）的胰胆锌分泌均低于饮食锌充足的受试者。与胰胆铜分泌明显减少形成对比的是，未接受锌治疗的威尔逊病患者基础状态下（226.6±126 nmol/L/分钟）和刺激后（728.7±195.5 nmol/L/分钟）的锌分泌正常。这些研究表明，健康受试者的胰胆液中分泌有相当数量的锌，威尔逊病患者的锌分泌没有受损。我们的数据还表明，胰胆锌分泌取决于受试者的锌状态，提示内源性锌分泌可能在锌的体内平衡中起重要作用。
