动脉导管闭合的研究。X. 前列腺素的体内效应。

Studies on closure of the ductus arteriosus. X. In vivo effect of prostaglandin.

作者信息

Sharpe G L, Larsson K S

出版信息

Prostaglandins. 1975 May;9(5):703-19. doi: 10.1016/0090-6980(75)90109-4.

Abstract

The effect of prostaglandins F2alpha, E1 and of 7-oxa-13-prostynoic acid on the newborn rabbit ductus can be studied using the whole-body freezing technique. PGF2alpha and PGE1 were able to re-open the closing ductus arteriosus in adequately oxygenated animals. PGF2alpha administration was accompanied by a strong physical reaction in the rat but less in the rabbit. PGE1 had sedative effects in both animals. A prostaglandin antagonist, 7-oxa-13-prostynoic acid had no effect on normal ductal closure nor did it counteract the effects of PGF2alpha and PGE1. The role of prostaglandins in homeostasis during the fetal and newborn period may be to modify ductal tone.

摘要

使用全身冷冻技术可以研究前列腺素F2α、E1以及7-氧杂-13-前列腺炔酸对新生兔动脉导管的影响。在充分氧合的动物中，PGF2α和PGE1能够使闭合中的动脉导管重新开放。给大鼠注射PGF2α会伴随强烈的身体反应，但对兔的影响较小。PGE1对两种动物均有镇静作用。前列腺素拮抗剂7-氧杂-13-前列腺炔酸对正常导管闭合没有影响，也不能抵消PGF2α和PGE1的作用。前列腺素在胎儿期和新生儿期体内平衡中的作用可能是调节导管张力。