什么？多胺生物合成抑制剂 DFMO 在化学预防中的作用是由于胸苷池减少的结果？
Say what? The activity of the polyamine biosynthesis inhibitor difluoromethylornithine in chemoprevention is a result of reduced thymidine pools?
机构信息
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
出版信息
Cancer Discov. 2013 Sep;3(9):975-7. doi: 10.1158/2159-8290.CD-13-0427.
Abstract
In this issue of Cancer Discovery, Witherspoon and colleagues use an unbiased metabolite profiling approach to study the effects of polyamine depletion by 2-difluoromethylornithine in colon cancer cells. Their surprising findings indicate that it is a decrease in thymidine pools resulting from altered tetrahydrofolate availability rather than decreases in polyamines that produces cytostasis.
摘要
在本期《癌症发现》中，Witherspoon 及其同事采用一种无偏的代谢物分析方法，研究了二氟甲基鸟氨酸抑制多胺合成对结肠癌细胞的影响。他们的研究结果令人惊讶，表明细胞生长停滞的原因是由于四氢叶酸供应改变导致胸苷池减少，而不是多胺减少。
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