Riad Hassan, Shaikha Samya Abu, Ansari Hamda Al, Naama Khalifa Al, Sada Hussein Al, Mansoori Mariam Al
Hamad Medical Corporation, Doha, Qatar.
Case Rep Dermatol. 2013 Aug 14;5(2):219-24. doi: 10.1159/000354593. eCollection 2013.
Biologics are very useful medications that changed the lives of many patients in the last decade. However, we still do not know about the long-term side effects of these drugs. Infliximab is an anti-TNF chimeric antibody widely used and approved for the treatment of many diseases. Lupus-like syndrome and hepatitis are among the uncommon side effects of infliximab. Most of the written literature was published for cases of rheumatology and gastroenterology. We report here a case of both hepatitis and lupus-like syndrome that occurred sequentially in the same patient and compare our finding with two case reports of the same side effects, drug and disease.
生物制剂是非常有用的药物，在过去十年中改变了许多患者的生活。然而，我们仍然不清楚这些药物的长期副作用。英夫利昔单抗是一种抗TNF嵌合抗体，广泛用于治疗多种疾病并已获批准。狼疮样综合征和肝炎是英夫利昔单抗不常见的副作用。大多数书面文献是关于风湿病和胃肠病病例的报道。我们在此报告一例同一患者先后出现肝炎和狼疮样综合征的病例，并将我们的发现与另外两例关于相同副作用、药物和疾病的病例报告进行比较。
