贝伐单抗对松果体区复发性乳头状肿瘤有效：首例报告

Cohen Adam L, Salzman Karen, Palmer Cheryl, Jensen Randy, Colman Howard

Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.

Case Rep Oncol. 2013 Aug 24;6(2):434-40. doi: 10.1159/000354753. eCollection 2013.

Papillary tumor of the pineal region (PTPR) is a rare brain tumor that probably arises from ependymal cells. There are no known systemic treatments for PTPR once it is refractory to surgery and radiation. We present the first case of a durable radiographic and clinical response of a PTPR to bevacizumab, an antibody against vascular endothelial growth factor, despite multiple prior treatments. Bevacizumab may be an effective treatment for PTPR.

松果体区乳头状肿瘤（PTPR）是一种罕见的脑肿瘤，可能起源于室管膜细胞。一旦PTPR对手术和放疗无效，目前尚无已知的全身治疗方法。我们报告了首例PTPR患者，尽管此前接受过多种治疗，但使用抗血管内皮生长因子抗体贝伐单抗后，在影像学和临床方面均取得了持久的缓解。贝伐单抗可能是治疗PTPR的有效方法。