D'Alò D, Bernardini I, Cioccoloni F, Calagreti G, Leite S, Petrucci M Saba, Bianconi F, Brunori V, La Rosa F, Stracci F
Department of Medical-Surgical Specialties & Public Health, Public Health Section, University of Perugia, Perugia, Italy.
Eur J Gynaecol Oncol. 2013;34(4):311-8.
The authors describe the incidence and mortality rates of human papillomavirus (HPV)-related female cancers in Umbria (Italy) in the pre-vaccination period from 1978-2008. Joinpoint regression was applied on age-adjusted incidence and mortality rates to evaluate temporal trends. Mouth and pharynx cancers incidence and mortality trends decreased about three percent per year. For anus and anal canal cancer, incidence and mortality trends presented a non-significant decrease. For malignant neoplasm of vulva, a significant change was found in incidence trend: the annual percentage change decreased from 2001 (- 1.8%). Mortality trend showed a non-significant decrease. Incidence and mortality rates from vaginal cancer were non-significantly decreased. For malignant neoplasm of cervix uteri, incidence rates showed a significant decrease by 2.1% per year. Mortality rates decreased as well, although non-significantly. HPV-related cancers consistently decreased in Umbria. This trend may be a consequence of safer sexual behavior. For cervical cancer, a combination of opportunistic and programmed screening led to a much-reduced disease burden. It is expected that the implementation of vaccination in the future will lead to a further decrease of HPV-related cancer incidence and mortality.
作者描述了1978年至2008年疫苗接种前意大利翁布里亚地区人乳头瘤病毒（HPV）相关女性癌症的发病率和死亡率。对年龄调整后的发病率和死亡率应用连接点回归来评估时间趋势。口腔和咽癌的发病率和死亡率趋势每年下降约3%。对于肛门和肛管癌，发病率和死亡率趋势呈非显著性下降。对于外阴恶性肿瘤，发病率趋势有显著变化：年变化率从2001年开始下降（-1.8%）。死亡率趋势呈非显著性下降。阴道癌的发病率和死亡率呈非显著性下降。对于子宫颈恶性肿瘤，发病率每年显著下降2.1%。死亡率也有所下降，尽管不显著。翁布里亚地区HPV相关癌症持续下降。这种趋势可能是性行为更安全的结果。对于宫颈癌，机会性筛查和计划性筛查相结合使疾病负担大大减轻。预计未来实施疫苗接种将导致HPV相关癌症的发病率和死亡率进一步下降。
