Economic Evaluation and HTA (EEHTA), CEIS, Faculty of Economics, University of Rome 'Tor Vergata', Via Columbia, 2, Roma, RM, Italy.
Institute of Leadership and Management in Health, Kingston University, London, UK.
Clin Drug Investig. 2018 Feb;38(2):173-180. doi: 10.1007/s40261-017-0597-x.
HPV (human papillomavirus) is the virus most often responsible for sexually transmitted infections. The burden of HPV-related diseases on hospital resources represents a major public health problem. The aim of this study was to assess the economic burden of HPV-related diseases (anal cancer, genital cancer, genital warts, oropharyngeal cancer) on hospital resources in two Italian regions.
A retrospective, non-randomized, observational study was developed in the Marche and Veneto Regions, based on patients receiving hospitalization between 2008 and 2011. All hospitalizations were identified through administrative archives, according to the International Classification of Diseases (ICD-9 CM) to which a defined tariff was assigned.
We identified 5299 hospitalized patients in Veneto and 1735 in the Marche Region. The mean annual hospitalization rate was 49.44 per 100,000 individuals in Veneto and 48.41 in Marche. The total mean annual cost attributable to HPV-related diseases was €5.78 (SD 0.80) million in Veneto and €2.24 (SD 0.17) million in Marche. Costs associated with genital cancer amounted to €1.61 million in Veneto and €1.06 million in Marche (28% and 47% of the total mean annual cost, respectively). Oropharyngeal cancer accounted for 36% in Veneto (€2.08 million) and 28% in Marche (€632,645). Hospitalization costs related to anal cancer were €882,567 in Veneto and €377,719 in Marche; genital warts accounted for €1.19 million in Veneto and €171,406 in Marche. Finally, the mean cost per patient was €4364 in Veneto and €5176 in Marche.
The present work estimated the cost of HPV-related diseases for hospitalized patients in two Italian regions. The considerable estimated annual economic burden is a powerful driver for the governance of the public health sector.
HPV（人乳头瘤病毒）是最常导致性传播感染的病毒。HPV 相关疾病对医院资源造成的负担是一个主要的公共卫生问题。本研究的目的是评估 HPV 相关疾病（肛门癌、生殖器癌、生殖器疣、口咽癌）对意大利两个地区医院资源的经济负担。
在马尔凯和威尼托地区进行了一项回顾性、非随机、观察性研究，该研究基于 2008 年至 2011 年间接受住院治疗的患者。所有住院治疗均通过行政档案根据国际疾病分类（ICD-9 CM）进行识别，并为其分配了一个明确的费率。
我们在威尼托地区发现了 5299 例住院患者，在马尔凯地区发现了 1735 例。威尼托地区的年平均住院率为每 10 万人 49.44 例，马尔凯地区为 48.41 例。归因于 HPV 相关疾病的总平均年费用在威尼托为 578 万欧元（标准差 0.80），在马尔凯为 224 万欧元（标准差 0.17）。生殖器癌相关费用在威尼托为 161 万欧元，在马尔凯为 106 万欧元（分别占总平均年费用的 28%和 47%）。口咽癌在威尼托占 36%（208 万欧元），在马尔凯占 28%（632645 欧元）。威尼托的肛门癌住院费用为 882567 欧元，马尔凯为 377719 欧元；威尼托的生殖器疣费用为 119 万欧元，马尔凯为 171406 欧元。最后，威尼托的每位患者平均费用为 4364 欧元，马尔凯为 5176 欧元。
本研究估计了意大利两个地区住院患者 HPV 相关疾病的成本。估计的年度经济负担相当大，是公共卫生部门治理的强大驱动力。
