Nishida K, Nagamura Y, Ogitsu N, Ishiguro I, Ito M
Department of Biochemistry, School of Hygiene, Fujita Health University, Toyoake.
Rinsho Byori. 1990 Jul;38(7):835-7.
The concentrations of specific terminal sugar residues of glycoproteins were determined in sera of patients with diabetes, liver injury or complication of both diseases. A significant increase in serum galactose (Gal) concentration was found in all patients. Serum N-acetylneuraminic acid-galactose (NANA-Gal) concentration was significantly decreased in patients with complication of diabetes and liver injury, whereas a high concentration of serum N-acetylneuraminic acid (NANA) was observed only in diabetic patients. Thus the determination of serum Gal and NANA-Gal should be added to one of clinical tests to provide new information on the pathological conditions of diabetes and liver injury.
测定了糖尿病患者、肝损伤患者或患有这两种疾病并发症患者血清中糖蛋白特定末端糖残基的浓度。所有患者的血清半乳糖（Gal）浓度均显著升高。糖尿病和肝损伤并发症患者的血清N-乙酰神经氨酸-半乳糖（NANA-Gal）浓度显著降低，而仅在糖尿病患者中观察到高浓度的血清N-乙酰神经氨酸（NANA）。因此，血清Gal和NANA-Gal的测定应添加到临床检测项目中，以提供有关糖尿病和肝损伤病理状况的新信息。
