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尸体血液糖化血红蛋白的测定:一项涉及使用间氨基苯硼酸亲和色谱法的研究。

Determination of glycated hemoglobins of cadaveric blood: a study involving the use of affinity chromatography with m-amino phenyl boronic acid.

作者信息

Kuroda N

机构信息

Department of Legal Medicine, School of Medicine, Keio University, Tokyo, Japan.

出版信息

Nihon Hoigaku Zasshi. 1990 Apr;44(2):115-25.

PMID:2402096
Abstract

For a postmortem diagnosis of diabetes mellitus (DM), the applicability of achieving a determination by examining the glycated hemoglobins (GHb) is discussed. Experimental studies by the use of affinity chromatography with m-amino phenyl boronic acid-agarose revealed that the GHb values could be determined stably and could be reproduced even for some postmortem models of both non-diabetic and diabetic human blood. A subsequent survey of autopsy cases with a proper past DM medical history has suggested that this method is useful, especially when used with customary medicolegal examinations conducted for DM.

摘要

对于糖尿病(DM)的尸检诊断,讨论了通过检测糖化血红蛋白(GHb)进行测定的适用性。使用间氨基苯硼酸 - 琼脂糖亲和色谱法进行的实验研究表明,即使对于非糖尿病和糖尿病患者血液的一些尸检模型,GHb值也能够稳定测定且可重复。随后对有适当糖尿病既往病史的尸检病例进行的调查表明,该方法很有用,特别是与针对糖尿病进行的常规法医学检查一起使用时。

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Determination of glycated hemoglobins of cadaveric blood: a study involving the use of affinity chromatography with m-amino phenyl boronic acid.尸体血液糖化血红蛋白的测定:一项涉及使用间氨基苯硼酸亲和色谱法的研究。
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