比较乳腺和腹部脂肪组织间充质基质/干细胞对乳腺癌细胞增殖的支持作用。
Comparison of breast and abdominal adipose tissue mesenchymal stromal/stem cells in support of proliferation of breast cancer cells.
机构信息
Department of Medicine, University of Wisconsin-Madison, School of Medicine and Public Health , Madison, Wisconsin , USA,1.
出版信息
Cancer Invest. 2013 Oct;31(8):550-4. doi: 10.3109/07357907.2013.830737. Epub 2013 Sep 10.
Abstract
In this study, we compared MSCs from breast and abdominal tissue in terms of their expression of genes deemed important in the support of breast cancer growth and their effect on gene profile of macrophages after coculture. In addition, we investigated the role of MSCs, alone or in combination with macrophages, on proliferation of breast cancer cell lines. Our results show that MSCs derived from breast and abdominal adipose tissues have a comparable gene expression profile, have similar effect on gene expression of macrophages, and are comparable in supporting breast cancer cell line proliferation.
摘要
在这项研究中，我们比较了来自乳房和腹部组织的间充质干细胞，比较了它们在支持乳腺癌生长方面的重要基因表达及其与巨噬细胞共培养后的基因谱的影响。此外，我们还研究了间充质干细胞单独或与巨噬细胞联合对乳腺癌细胞系增殖的作用。我们的结果表明，来自乳房和腹部脂肪组织的间充质干细胞具有相似的基因表达谱，对巨噬细胞基因表达的影响相似，并且在支持乳腺癌细胞系增殖方面也相似。
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本文引用的文献
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