Gallo C, Poletti G, Cazorla A
Depto. de Ciencias Fisiológicas, Universidad Peruana Cayetano Heredia, Lima, Perú.
Life Sci. 1990;47(6):507-13. doi: 10.1016/0024-3205(90)90610-4.
In order to test the effects of chronic lithium (Li) administration on learning and memory, 21 day old rats were subjected to different degrees of environmental stimulation (enriched condition, EC and impoverished condition, IC) with and without Li for 144 days. Li was administered with food (2.18 mEq/Kg weight/day). Average plasma Li concentration at the end of the experiment was 0.41 +/- 0.04 mu Eq/ml. Both Li treatment and the environmental condition showed an overall significant effect on the cortex/subcortex weight ratio and learning ability index, but not on AChE activity in occipital cortex. A similar pattern of brain Li distribution was observed in both EC-Li and IC-Li, with occipital cortex having the highest levels. Li tissue/protein/plasma ratio was higher in EC than in IC, in all the brain areas studied. Other organs (liver and kidney) did not show EC-IC differences in the tissue/protein/plasma Li ratio.
为了测试长期给予锂（Li）对学习和记忆的影响，对21日龄大鼠在有或无锂的情况下进行不同程度的环境刺激（丰富环境条件，EC和贫乏环境条件，IC），持续144天。锂与食物一起给予（2.18 mEq/千克体重/天）。实验结束时的平均血浆锂浓度为0.41±0.04微当量/毫升。锂处理和环境条件对皮质/皮质下重量比和学习能力指数均显示出总体显著影响，但对枕叶皮质中的乙酰胆碱酯酶活性没有影响。在EC-Li和IC-Li中均观察到相似的脑锂分布模式，枕叶皮质中的锂含量最高。在所有研究的脑区中，EC组的锂组织/蛋白质/血浆比率高于IC组。其他器官（肝脏和肾脏）在组织/蛋白质/血浆锂比率方面未显示出EC与IC之间的差异。
