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First Axl inhibitor enters clinical trials.

作者信息

Sheridan Cormac

出版信息

Nat Biotechnol. 2013 Sep;31(9):775-6. doi: 10.1038/nbt0913-775a.

DOI:10.1038/nbt0913-775a
PMID:24022140
Abstract
摘要

相似文献

1
First Axl inhibitor enters clinical trials.首款Axl抑制剂进入临床试验。
Nat Biotechnol. 2013 Sep;31(9):775-6. doi: 10.1038/nbt0913-775a.
2
Axl and Mer Receptor Tyrosine Kinases: Distinct and Nonoverlapping Roles in Inflammation and Cancer?Axl和Mer受体酪氨酸激酶：在炎症和癌症中具有不同且不重叠的作用？
Adv Exp Med Biol. 2016;930:113-32. doi: 10.1007/978-3-319-39406-0_5.
3
Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine derivatives as novel selective Axl inhibitors.发现 5,6,7,8-四氢吡啶并[3,4-d]嘧啶衍生物为新型选择性 Axl 抑制剂。
Bioorg Med Chem Lett. 2021 Sep 15;48:128247. doi: 10.1016/j.bmcl.2021.128247. Epub 2021 Jul 13.
4
Role of the Receptor Tyrosine Kinase Axl and its Targeting in Cancer Cells.受体酪氨酸激酶Axl在癌细胞中的作用及其靶向治疗
Curr Med Chem. 2016;23(15):1496-512. doi: 10.2174/0929867323666160405112954.
5
Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate.利用Mer突变体替代物对作为Axl激酶抑制剂的1H-咪唑-2-甲酰胺进行基于结构的优化。
Bioorg Med Chem Lett. 2017 Feb 15;27(4):1099-1104. doi: 10.1016/j.bmcl.2016.12.024. Epub 2016 Dec 20.
6
Axl inhibitors as novel cancer therapeutic agents.AXL 抑制剂作为新型癌症治疗药物。
Life Sci. 2018 Apr 1;198:99-111. doi: 10.1016/j.lfs.2018.02.033. Epub 2018 Feb 27.
7
Activation of HER3 interferes with antitumor effects of Axl receptor tyrosine kinase inhibitors: suggestion of combination therapy.激活 HER3 会干扰 Axl 受体酪氨酸激酶抑制剂的抗肿瘤作用：联合治疗的建议。
Neoplasia. 2014 Apr;16(4):301-18. doi: 10.1016/j.neo.2014.03.009.
8
Key Roles of AXL and MER Receptor Tyrosine Kinases in Resistance to Multiple Anticancer Therapies.AXL和MER受体酪氨酸激酶在多种抗癌疗法耐药性中的关键作用
Curr Oncol Rep. 2017 Mar;19(3):19. doi: 10.1007/s11912-017-0579-4.
9
Immuno-oncological Efficacy of RXDX-106, a Novel TAM (TYRO3, AXL, MER) Family Small-Molecule Kinase Inhibitor.RXDX-106，一种新型 TAM（TYRO3、AXL、MER）家族小分子激酶抑制剂的免疫肿瘤学疗效。
Cancer Res. 2019 Apr 15;79(8):1996-2008. doi: 10.1158/0008-5472.CAN-18-2022. Epub 2019 Feb 5.
10
Opposing Roles of Tyrosine Kinase Receptors Mer and Axl Determine Clinical Outcomes in Experimental Immune-Mediated Nephritis.酪氨酸激酶受体Mer和Axl的相反作用决定了实验性免疫介导性肾炎的临床结果。
J Immunol. 2016 Sep 15;197(6):2187-94. doi: 10.4049/jimmunol.1600793. Epub 2016 Aug 15.

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AXL as immune regulator and therapeutic target in Acute Myeloid Leukemia: from current progress to novel strategies.AXL作为急性髓系白血病中的免疫调节因子和治疗靶点：从当前进展到新策略
Exp Hematol Oncol. 2024 Oct 4;13(1):99. doi: 10.1186/s40164-024-00566-8.
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Development of nanoparticles incorporated with quercetin and ACE2-membrane as a novel therapy for COVID-19.将槲皮素和 ACE2 膜结合的纳米粒子开发为 COVID-19 的新型治疗方法。
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本文引用的文献

1
Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer.原癌基因 Axl 和 Mer 受体酪氨酸激酶在结肠癌中的矛盾作用。
Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13091-6. doi: 10.1073/pnas.1302507110. Epub 2013 Jul 22.
2
Gas6/Axl mediates tumor cell apoptosis, migration and invasion and predicts the clinical outcome of osteosarcoma patients.Gas6/Axl 介导肿瘤细胞凋亡、迁移和侵袭，并预测骨肉瘤患者的临床结局。
Biochem Biophys Res Commun. 2013 Jun 7;435(3):493-500. doi: 10.1016/j.bbrc.2013.05.019. Epub 2013 May 15.
3
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer.
细胞力学转导在健康与疾病中的作用：从分子机制到治疗靶点。
Signal Transduct Target Ther. 2023 Jul 31;8(1):282. doi: 10.1038/s41392-023-01501-9.
4
Integrin β3 Promotes Resistance to EGFR-TKI in Non-Small-Cell Lung Cancer by Upregulating AXL through the YAP Pathway.整合素 β3 通过 YAP 通路上调 AXL 促进非小细胞肺癌对 EGFR-TKI 的耐药性。
Cells. 2022 Jun 30;11(13):2078. doi: 10.3390/cells11132078.
5
Endocytic trafficking of GAS6-AXL complexes is associated with sustained AKT activation.GAS6-AXL 复合物的内吞运输与持续的 AKT 激活有关。
Cell Mol Life Sci. 2022 May 27;79(6):316. doi: 10.1007/s00018-022-04312-3.
6
Decoding cancer's camouflage: epithelial-mesenchymal plasticity in resistance to immune checkpoint blockade.解码癌症的伪装：上皮-间质可塑性与免疫检查点阻断耐药性
Cancer Drug Resist. 2020 Oct 12;3(4):832-853. doi: 10.20517/cdr.2020.41. eCollection 2020.
7
Therapeutic progress and challenges for triple negative breast cancer: targeted therapy and immunotherapy.三阴性乳腺癌的治疗进展与挑战：靶向治疗和免疫治疗
Mol Biomed. 2022 Mar 4;3(1):8. doi: 10.1186/s43556-022-00071-6.
8
Anti-Axl monoclonal antibodies attenuate the migration of MDA-MB-231 breast cancer cells.抗Axl单克隆抗体可减弱MDA-MB-231乳腺癌细胞的迁移能力。
Oncol Lett. 2021 Nov;22(5):749. doi: 10.3892/ol.2021.13010. Epub 2021 Aug 27.
9
Targeting AXL in NSCLC.在非小细胞肺癌中靶向AXL
Lung Cancer (Auckl). 2021 Aug 10;12:67-79. doi: 10.2147/LCTT.S305484. eCollection 2021.
10
Dual targeting of TAM receptors Tyro3, Axl, and MerTK: Role in tumors and the tumor immune microenvironment.TAM 受体 Tyro3、Axl 和 MerTK 的双重靶向作用：在肿瘤及肿瘤免疫微环境中的作用
Tzu Chi Med J. 2020 Oct 15;33(3):250-256. doi: 10.4103/tcmj.tcmj_129_20. eCollection 2021 Jul-Sep.
AXL 激酶的激活导致肺癌对 EGFR 靶向治疗产生耐药性。
Nat Genet. 2012 Jul 1;44(8):852-60. doi: 10.1038/ng.2330.
4
R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer.R428 是一种选择性的 Axl 激酶小分子抑制剂，可阻止转移性乳腺癌模型中的肿瘤扩散并延长生存期。
Cancer Res. 2010 Feb 15;70(4):1544-54. doi: 10.1158/0008-5472.CAN-09-2997. Epub 2010 Feb 9.
5
Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival.Axl 是乳腺癌转移和患者生存的上皮-间充质转化诱导调节因子。
Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1124-9. doi: 10.1073/pnas.0909333107. Epub 2009 Dec 28.
6
Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme.Axl和生长停滞特异性基因6在人类胶质瘤中经常过度表达，并预示多形性胶质母细胞瘤患者的预后不良。
Clin Cancer Res. 2008 Jan 1;14(1):130-8. doi: 10.1158/1078-0432.CCR-07-0862.
7
TAM receptors are pleiotropic inhibitors of the innate immune response.酪氨酸激酶受体（TAM）是先天性免疫反应的多效性抑制剂。
Cell. 2007 Dec 14;131(6):1124-36. doi: 10.1016/j.cell.2007.10.034.