Department of Applied Chemistry, Dongduk Women's University, 23-1 Wolgok-dong, Sungbuk-ku, Seoul 136-714, Korea.
Nutrients. 2013 Sep 9;5(9):3496-505. doi: 10.3390/nu5093496.
The effect of high doses of vitamin C for the treatment of cancer has been controversial. Our previous studies, and studies by others, have reported that vitamin C at concentrations of 0.25-1.0 mM induced a dose- and time-dependent inhibition of proliferation in acute myeloid leukemia (AML) cell lines and in leukemic cells from peripheral blood specimens obtained from patients with AML. Treatment of cells with high doses of vitamin C resulted in an immediate increase in intracellular total glutathione content and glutathione-S transferase activity that was accompanied by the uptake of cysteine. These results suggest a new role for high concentrations of vitamin C in modulation of intracellular sulfur containing compounds, such as glutathione and cysteine. This review, discussing biochemical pharmacologic studies, including pharmacogenomic and pharmacoproteomic studies, presents the different pharmacological effects of vitamin C currently under investigation.
大剂量维生素 C 治疗癌症的效果一直存在争议。我们之前的研究和其他研究报告指出,浓度为 0.25-1.0mM 的维生素 C 会抑制急性髓系白血病(AML)细胞系和来自 AML 患者外周血标本的白血病细胞的增殖,且呈剂量和时间依赖性。用大剂量维生素 C 处理细胞会立即增加细胞内总谷胱甘肽含量和谷胱甘肽-S 转移酶活性,同时摄取半胱氨酸。这些结果表明,高浓度维生素 C 在调节细胞内含硫化合物(如谷胱甘肽和半胱氨酸)方面具有新的作用。这篇综述讨论了生化药理学研究,包括遗传药理学和蛋白质组学研究,介绍了目前正在研究的维生素 C 的不同药理作用。