Department of Radiology and ‡Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre , 6500HB Nijmegen, The Netherlands.
ACS Chem Neurosci. 2013 Nov 20;4(11):1417-29. doi: 10.1021/cn4001582. Epub 2013 Sep 26.
Alzheimer's disease (AD) is the most common form of dementia. During the recent decade, nanotechnology has been widely considered, as a promising tool, for theranosis (diagnosis and therapy) of AD. Here we first discuss pathophysiology and characteristics of AD with a focus on the amyloid cascade hypothesis. Then magnetic nanoparticles (MNPs) and recent works on their applications in AD, focusing on the superparamagnetic iron oxide nanoparticles (SPIONs), are reviewed. Furthermore, the amyloid-nanoparticle interaction is highlighted, with the scope to be highly considered by the scientists aiming for diagnostics and/or treatment of AD employing nanoparticles. Furthermore, recent findings on the "ignored" parameters (e.g., effect of protein "corona" at the surface of nanoparticles on amyloid-β (Aβ) fibrillation process) are discussed.
阿尔茨海默病（AD）是最常见的痴呆症形式。在最近的十年中，纳米技术被广泛认为是 AD 的治疗（诊断和治疗）的有前途的工具。在这里，我们首先讨论 AD 的病理生理学和特征，重点是淀粉样蛋白级联假说。然后综述了磁性纳米粒子（MNPs）及其在 AD 中的应用的最新研究进展，重点是超顺磁氧化铁纳米粒子（SPIONs）。此外，还强调了淀粉样蛋白-纳米粒子的相互作用，旨在引起希望利用纳米粒子进行 AD 的诊断和/或治疗的科学家的高度重视。此外，还讨论了最近关于“被忽视”参数的发现（例如，纳米粒子表面上的蛋白质“冠”对淀粉样蛋白-β（Aβ）纤维化过程的影响）。
