钌催化吲哚和吡咯的 C2 区域选择性烯基化反应通过 C-H 键功能化。
Ruthenium-catalyzed regioselective C2 alkenylation of indoles and pyrroles via C-H bond functionalization.
机构信息
State Key Laboratory of Element-Organic Chemistry, Synergetic Innovation Center of Chemical Science and Engineering, College of Chemistry, Nankai University , Tianjin 300071, P. R. China.
出版信息
J Org Chem. 2013 Sep 20;78(18):9345-53. doi: 10.1021/jo401579m. Epub 2013 Sep 11.
PMID:24025192
Abstract
An efficient ruthenium-catalyzed oxidative coupling of indoles and pyrroles with various alkenes at the C2-position assisted by employing the N,N-dimethylcarbamoyl moiety as a directing group is reported. The catalytic reaction proceeds in an excellent regio- and stereoselective manner.
摘要
本文报道了一种高效的钌催化吲哚和吡咯与各种烯烃在 C2 位的氧化偶联反应，该反应采用 N,N-二甲基氨基甲酰基作为导向基团。该催化反应具有优异的区域和立体选择性。
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