维生素 D 与心脏。
Vitamin D and the heart.
机构信息
Diabetes Center, University of California at San Francisco, San Francisco, California; and.
出版信息
Am J Physiol Regul Integr Comp Physiol. 2013 Nov 1;305(9):R969-77. doi: 10.1152/ajpregu.00322.2013. Epub 2013 Sep 11.
Abstract
Vitamin D receptors (VDR) are found in cells throughout the cardiovascular system. A variety of experimental studies indicate that the liganded VDR may play an important role in controlling cardiac hypertrophy and fibrosis, regulating blood pressure, and suppressing the development of atherosclerosis. Some, but not all, observational studies in humans provide support for these experimental findings, raising the possibility that vitamin D or its analogs might prove useful therapeutically in the prevention or treatment of cardiovascular disease.
摘要
维生素 D 受体 (VDR) 存在于心血管系统的各种细胞中。多种实验研究表明，配体结合的 VDR 可能在控制心脏肥大和纤维化、调节血压和抑制动脉粥样硬化发展方面发挥重要作用。一些，但不是全部，人类的观察性研究为这些实验结果提供了支持，这增加了维生素 D 或其类似物在心血管疾病的预防或治疗中可能具有治疗价值的可能性。
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