León Ignacio E, Etcheverry Susana B, Parajón-Costa Beatriz S, Baran Enrique J
Cátedra de Bioquímica Patológica, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900, La Plata, Argentina.
Biol Trace Elem Res. 2013 Nov;155(2):295-300. doi: 10.1007/s12011-013-9787-4. Epub 2013 Sep 12.
Two structurally related vanadium(V) complexes, K3[VO2(C2O4)2] · 3H2O and K3[VO(O2)(C2O4)2] · 1/2H2O, were thoroughly characterized by infrared, Raman, and electronic spectroscopies. The effect of both complexes on the viability of the human MG-63 osteosarcoma cells was tested using the MTT assay. The monoperoxo complex shows a very strong antiproliferative activity (at 100-μM concentration, this complex diminished the cell viability ca. 80 %), whereas the dioxo complex was inactive.
通过红外光谱、拉曼光谱和电子光谱对两种结构相关的钒（V）配合物K3[VO2(C2O4)2]·3H2O和K3[VO(O2)(C2O4)2]·1/2H2O进行了全面表征。使用MTT法测试了这两种配合物对人MG-63骨肉瘤细胞活力的影响。单过氧配合物表现出非常强的抗增殖活性（在100μM浓度下，该配合物使细胞活力降低约80%），而二氧配合物则无活性。
