León Ignacio E, Parajón-Costa Beatriz S, Franca Carlos A, Etcheverry Susana B, Baran Enrique J
Cátedra de Bioquímica Patológica, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900, La Plata, Argentina.
Biol Trace Elem Res. 2015 Apr;164(2):198-204. doi: 10.1007/s12011-014-0206-2. Epub 2014 Dec 23.
The oxidovanadium(IV) complex of oxodiacetic acid (H2ODA) and dppz (dipyrido[3,2-a:2',3'-c] phenazine) of stoichiometry [VO(ODA)(dppz)]·3H2O could be synthesized for the first time by reaction between [VO(ODA)(H2O)2] and dppz. It was characterized by infrared and electronic spectroscopies. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for crystallographic studies. The antitumor action of the complex on MG-63 human osteosarcoma cell line was also investigated. It was found that it caused a concentration-related inhibitory effect in the concentration range between 5 and 25 μM and diminished the cell viability ca. 45% in the range from 25 to 100 μM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)(ophen)]·1.5H2O complex.
通过[VO(ODA)(H₂O)₂]与dppz（二吡啶并[3,2 - a:2',3'- c]吩嗪）反应，首次合成了化学计量比为[VO(ODA)(dppz)]·3H₂O的氧代二乙酸（H₂ODA）和dppz的氧化钒（IV）配合物。通过红外光谱和电子光谱对其进行了表征。由于无法生长出适合晶体学研究的单晶，通过密度泛函理论（DFT）计算获得了其优化的分子结构。还研究了该配合物对MG - 63人骨肉瘤细胞系的抗肿瘤作用。结果发现，在5至25 μM的浓度范围内，它产生了浓度相关的抑制作用，在25至100 μM的范围内，细胞活力降低了约45%，在此范围内没有剂量/反应效应。总体而言，这些生物学效应与先前报道的相关[VO(ODA)(ophen)]·1.5H₂O配合物的效应相似。
