Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany), Fax: (+49) 2083062974.
Chemistry. 2013 Sep 27;19(40):13274-87. doi: 10.1002/chem.201301522. Epub 2013 Sep 11.
The direct functionalization of C-H bonds is an attractive strategy in organic synthesis. Although several advances have been made in this area, the selective activation of inert sp(3) C-H bonds remains a daunting challenge. Recently, a new type of sp(3) C-H activation mode through internal hydride transfer has demonstrated the potential to activate remote sp(3) C-H linkages in an atom-economic manner. This Minireview attempts to classify recent advances in this area including the transition to non-activated sp(3) C-H bonds and asymmetric hydride transfers.
C-H 键的直接官能化是有机合成中一种很有吸引力的策略。尽管在这一领域已经取得了一些进展，但惰性 sp(3) C-H 键的选择性活化仍然是一个艰巨的挑战。最近，一种新的 sp(3) C-H 活化模式通过内部氢化物转移，展示了以原子经济性方式活化远程 sp(3) C-H 键的潜力。本综述试图对这一领域的最新进展进行分类，包括向非活化的 sp(3) C-H 键的转变和不对称氢化物转移。
