Department of Applied Physics, Defence Institute of Advanced Technology (DU) , Girinagar, Pune 411025, India.
J Agric Food Chem. 2013 Oct 9;61(40):9632-7. doi: 10.1021/jf402894x. Epub 2013 Sep 26.
Curcumin, a yellow bioactive component of Indian spice turmeric, is known to have a wide spectrum of biological applications. In spite of various astounding therapeutic properties, it lacks in bioavailability mainly due to its poor solubility in water. In this work, we have conjugated curcumin with silica nanoparticles to improve its aqueous solubility and hence to make it more bioavailable. Conjugation and loading of curcumin with silica nanoparticles was further examined with transmission electron microscope (TEM) and thermogravimetric analyzer. Cytotoxicity analysis of synthesized silica:curcumin conjugate was studied against HeLa cell lines as well as normal fibroblast cell lines. This study shows that silica:curcumin conjugate has great potential for anticancer application.
姜黄，一种印度香料姜黄中的黄色生物活性成分，已知具有广泛的生物应用。尽管具有各种惊人的治疗特性，但由于其在水中的溶解度差，因此生物利用度低。在这项工作中，我们将姜黄素与硅纳米粒子结合，以提高其水溶解度，从而使其更具生物利用度。进一步用透射电子显微镜（TEM）和热重分析仪检查了姜黄素与硅纳米粒子的结合和负载。合成的硅纳米粒子：姜黄素缀合物对 HeLa 细胞系和正常成纤维细胞系的细胞毒性分析表明，硅纳米粒子：姜黄素缀合物在抗癌应用方面具有很大的潜力。
