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[青少年卵巢罕见恶性肿瘤——决定治疗积极性的临床因素]

[Rare malignant tumors of the ovaries in adolescents--clinical aspects in deciding therapeutic aggressiveness].

作者信息

Schröder W, Bau O

机构信息

Frauenklinik der Städtischen Kliniken Offenbach.

出版信息

Zentralbl Gynakol. 1990;112(10):633-40.

PMID:2402968
Abstract

4 patients below the age of 20 years have been treated for a malignant tumor of the ovary during the period November 1, 1984 until April 30, 1988. Dysgerminoma was the diagnosis in two cases, as the third patient suffered from a bilateral malignant teratoma. Burkitt's Lymphoma involved both ovaries primarily in an 17-year-old girl. Retrospectively we analyzed diagnosis, therapy and clinical course of these young patients. Regarding the different histological types of the tumors that have been found we discuss critically current recommendations in therapeutic managements referring chemotherapy and/or radiotherapy. Defined conditions provided surgical treatment, that preserves fertility in early stages of malignant germ cell tumors of adolescent women, may be justified, especially for dysgerminomas. A real benefit relate to survival and quality of life by using chemotherapeutic agents can only be expected, if all prognostic factors are regarded.

摘要

在1984年11月1日至1988年4月30日期间,有4名20岁以下的患者接受了卵巢恶性肿瘤的治疗。其中2例诊断为无性细胞瘤,第3例患者患有双侧恶性畸胎瘤。一名17岁女孩的双侧卵巢主要受累于伯基特淋巴瘤。我们回顾性分析了这些年轻患者的诊断、治疗和临床过程。针对所发现的不同组织学类型的肿瘤,我们批判性地讨论了目前关于化疗和/或放疗的治疗管理建议。对于青春期女性恶性生殖细胞肿瘤早期,在特定条件下进行保留生育功能的手术治疗可能是合理的,尤其是对于无性细胞瘤。只有在考虑所有预后因素的情况下,使用化疗药物才有望真正提高生存率和生活质量。

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