Sørensen T S, Sørensen A I, Merser S
Department of Clinical Microbiology, Frederiksberg Hospital, Denmark.
Acta Orthop Scand. 1990 Aug;61(4):353-6. doi: 10.3109/17453679008993535.
The gentamicin-containing collagen sponge is a new product intended for local application in bone and soft-tissue infections. The release of gentamicin from the collagen sponges was compared in vitro to that from polymethyl-methacrylate (PMMA) beads. A static and kinetic experimental design was used. In the static model, pieces of collagen sponge or PMMA beads were added to 20 mL of distilled water, and during the following hours the gentamicin concentrations in the water were repeatedly measured. This simple model was extended to the kinetic model as the released gentamicin was removed from the water exponentially by means of an infusion-withdrawal pump. The gentamicin was released from the carrier substances with increasing half lives. During the first 4 hours, the half life increased from 0.2 to 1.5 hours for the collagen sponge and from 3 to 78 hours for the PMMA beads. After 1.5 hours, 95 percent of the gentamicin was released from the sponges, whereas only 8 percent was released from the beads.
含庆大霉素的胶原海绵是一种用于骨和软组织感染局部应用的新产品。将胶原海绵中庆大霉素的释放情况与聚甲基丙烯酸甲酯（PMMA）珠中的释放情况进行了体外比较。采用了静态和动力学实验设计。在静态模型中，将胶原海绵片或PMMA珠加入20 mL蒸馏水中，在接下来的几个小时内反复测量水中的庆大霉素浓度。随着通过输液-抽取泵将释放的庆大霉素以指数方式从水中去除，这个简单模型扩展到了动力学模型。庆大霉素从载体物质中释放，半衰期不断增加。在最初的4小时内，胶原海绵的半衰期从0.2小时增加到1.5小时，PMMA珠的半衰期从3小时增加到78小时。1.5小时后，95%的庆大霉素从海绵中释放出来，而从珠子中仅释放出8%。
