Daskalopoulos Evangelos P, Janssen Ben J A, Blankesteijn W Matthijs
Department of Pharmacology, CARIM, Maastricht University, Maastricht, The Netherlands.
Methods Mol Biol. 2013;1037:355-80. doi: 10.1007/978-1-62703-505-7_21.
Myocardial infarction is one of the major causes of left ventricular dilatation, frequently leading to heart failure. In the last decade, the wound healing process that takes place in the infarct area after infarction has been recognized as a novel therapeutic target to attenuate left ventricular dilatation and preserve an adequate cardiac function. In this chapter, we discuss the role of Wnt signaling in the wound healing process after infarction, with a specific focus on its modulating effect on myofibroblast characteristics.
心肌梗死是左心室扩张的主要原因之一，常导致心力衰竭。在过去十年中，心肌梗死后梗死区域发生的伤口愈合过程已被视为减轻左心室扩张和维持足够心脏功能的新治疗靶点。在本章中，我们讨论Wnt信号在梗死后伤口愈合过程中的作用，特别关注其对肌成纤维细胞特性的调节作用。
