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1
Acceleration of autoimmunity in NZB/NZW F1 mice by graft-versus-host disease.移植物抗宿主病加速NZB/NZW F1小鼠的自身免疫反应。
Clin Exp Immunol. 1975 Feb;19(2):377-85.
2
Independent appearance of anti-thymocyte and anti-RNA antibodies in NZB/NZW F1 mice.抗胸腺细胞抗体和抗RNA抗体在NZB/NZW F1小鼠中的独立出现。
Immunology. 1975 Apr;28(4):621-8.
3
Effects of neonatal thymectomy and splenectomy on survival and regulation of autoantibody formation in NZB/NZW F1 mice.新生期胸腺切除和脾切除对NZB/NZW F1小鼠存活及自身抗体形成调节的影响。
J Immunol. 1977 May;118(5):1524-9.
4
Cellular basis of in vitro anti-DNA antibody production: evidence for T cell dependence of IgG-class anti-DNA antibody synthesis in the (NZB X NZW)F1 hybrid.体外抗DNA抗体产生的细胞基础：（新西兰黑鼠×新西兰白鼠）F1杂交种中IgG类抗DNA抗体合成依赖T细胞的证据。
J Immunol. 1986 Feb 15;136(4):1247-52.
5
Class-specific regulation of anti-DNA antibody synthesis and the age-associated changes in (NZB x NZW)F1 hybrid mice.抗DNA抗体合成的类别特异性调节以及（新西兰黑鼠×新西兰白鼠）F1杂交小鼠的年龄相关变化
J Immunol. 1987 May 1;138(9):2890-5.
6
Immunological regulation of spontaneous antibodies to DNA and RNA. II. Sequential switch from IgM to IgG in NZB/NZW F1 mice.针对DNA和RNA的天然抗体的免疫调节。II. NZB/NZW F1小鼠中从IgM到IgG的顺序转换
Immunology. 1977 Jan;32(1):75-9.
7
Animal models utilized in the research of autoimmune disease control: experimental therapy of glomerulonephritis in NZB/W F1 mice.用于自身免疫性疾病控制研究的动物模型：NZB/W F1小鼠肾小球肾炎的实验性治疗
Prog Clin Biol Res. 1987;229:157-74.
8
Autoimmunization in murine graft-vs-host disease. I. Selective production of antibodies to histones and DNA.小鼠移植物抗宿主病中的自身免疫。I. 针对组蛋白和DNA抗体的选择性产生。
J Immunol. 1985 Dec;135(6):3850-6.
9
Immunologic abnormality in NZB/NZW F1 mice. Thymus-independent occurrence of B cell abnormality and requirement for T cells in the development of autoimmune disease, as evidenced by an analysis of the athymic nude individuals.NZB/NZW F1小鼠的免疫异常。无胸腺裸鼠个体分析表明，B细胞异常不依赖胸腺发生，且自身免疫性疾病的发展需要T细胞。
J Immunol. 1988 Jul 1;141(1):85-90.
10
Treatment of NZB/W F1 mice with NZW splenic T cells or with serum of mice experiencing the graft-versus-host reaction: suppression of ongoing anti-double-stranded (ds) DNA antibody formation and improvement of renal function.用新西兰黑/新西兰白（NZB/W）F1小鼠的脾脏T细胞或经历移植物抗宿主反应的小鼠血清对NZB/W F1小鼠进行治疗：抑制正在进行的抗双链（ds）DNA抗体形成并改善肾功能。
Clin Immunol Immunopathol. 1984 Sep;32(3):359-67. doi: 10.1016/0090-1229(84)90279-4.

引用本文的文献

1
Increased survival times of New Zealand hybrid mice immunosuppressed by graft-versus-host reactions.因移植物抗宿主反应而免疫抑制的新西兰杂交小鼠存活时间延长。
Clin Exp Immunol. 1976 Aug;25(2):297-302.

本文引用的文献

1
Studies in experimental autoimmune disorders. I. Clinical and laboratory features of autoimmunization (runt disease) in the mouse.实验性自身免疫性疾病研究。I. 小鼠自身免疫（矮小病）的临床和实验室特征。
Blood. 1961 Jan;17:20-44.
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Thymus-marrow cell combinations. Synergism in antibody production.胸腺-骨髓细胞组合。抗体产生中的协同作用。
Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1167-71. doi: 10.3181/00379727-122-31353.
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Malignant lymphomas following allogenic disease: transition from an immunological to a neoplastic disorder.同种异体疾病后的恶性淋巴瘤：从免疫性疾病向肿瘤性疾病的转变。
Science. 1965 Sep 24;149(3691):1511-4. doi: 10.1126/science.149.3691.1511.
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Chronic allogeneic disease. II. Development of lymphomas.慢性同种异体疾病。II. 淋巴瘤的发展。
J Exp Med. 1970 Sep 1;132(3):417-39. doi: 10.1084/jem.132.3.417.
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Immunologic and viral factors in the pathogenesis of systemic lupus erythematosus.系统性红斑狼疮发病机制中的免疫和病毒因素
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DNA-binding assay for detection of anti-DNA antibodies in NZB-NZW F1 mice.用于检测NZB-NZW F1小鼠中抗DNA抗体的DNA结合试验。
J Immunol. 1969 Mar;102(3):788-90.
7
Natural thymocytotoxic autoantibody and reactive antigen in New Zealand black and other mice.新西兰黑鼠及其他小鼠中的天然胸腺细胞毒性自身抗体和反应性抗原。
Proc Natl Acad Sci U S A. 1971 Jul;68(7):1412-5. doi: 10.1073/pnas.68.7.1412.
8
Thymus dependence of cells in peripheral lymphoid tissues and in the circulation sensitive to natural thymocytotoxic autoantibody in NZB mice.NZB小鼠外周淋巴组织和循环中对天然胸腺细胞毒性自身抗体敏感的细胞的胸腺依赖性。
J Immunol. 1972 Jul;109(1):32-7.
9
Amplifying and suppressive effect of thymus cells.胸腺细胞的放大和抑制作用。
Nature. 1971 Dec 31;234(5331):549-51. doi: 10.1038/234549a0.
10
Chronic allogeneic disease. I. Development of glomerulonephritis.慢性同种异体疾病。I. 肾小球肾炎的发展。
J Exp Med. 1968 Oct 1;128(4):653-79. doi: 10.1084/jem.128.4.653.

移植物抗宿主病加速NZB/NZW F1小鼠的自身免疫反应。

Acceleration of autoimmunity in NZB/NZW F1 mice by graft-versus-host disease.

作者信息

Goldblum R, Pillarisetty R, Dauphinee M J, Talal N

出版信息

Clin Exp Immunol. 1975 Feb;19(2):377-85.

PMID:2403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1538084/
Abstract

Chronic graft-versus-host (GVH) disease was induced in NZB/NZW F1 (B/W) hybrid female mice by the weekly injection of parental NZB spleen cells. Control mice received injections of syngeneic spleen cells only. The mice were assayed for antibodies to [3H]DNA and [3H]polyadenylic-polyuridylic acid by a cellulose ester filter radioimmunoassay, and for antibody to thymocytes by a cytotoxicity method. GVH disease accelerated the development of all three antibodies in B/W mice. In addition, sucrose density gradient ultracentrifugation of pooled sera suggested that an accelerated switch from 19S to 7S anti-DNA production may be an early effect of GVH. The mechanism of acceleration is discussed in terms of immunological and viral factors generated by the GVH reaction.

摘要

通过每周注射亲代新西兰黑鼠脾脏细胞，在新西兰黑鼠/新西兰白鼠F1（B/W）杂交雌性小鼠中诱发慢性移植物抗宿主（GVH）病。对照小鼠仅注射同基因脾脏细胞。通过纤维素酯滤膜放射免疫测定法检测小鼠针对[3H]DNA和[3H]聚腺苷酸-聚尿苷酸的抗体，并通过细胞毒性方法检测针对胸腺细胞的抗体。GVH病加速了B/W小鼠中所有这三种抗体的产生。此外，对合并血清进行蔗糖密度梯度超速离心表明，从19S抗DNA产生加速转换为7S抗DNA产生可能是GVH的早期效应。从GVH反应产生的免疫和病毒因素方面讨论了加速机制。