癌症。循环肿瘤细胞。
Cancer. Circulating tumor cells.
机构信息
Department of Anatomy, University of California-San Francisco, San Francisco, CA 94143-0452, USA.
出版信息
Science. 2013 Sep 13;341(6151):1186-8. doi: 10.1126/science.1235226.
Abstract
Much remains to be learned about CTCs and their clinical potential as biomarkers and therapeutic targets.
摘要
关于 CTCs 及其作为生物标志物和治疗靶点的临床潜力，仍有许多需要了解。
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本文引用的文献
1
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay.
Nat Biotechnol. 2013 Jun;31(6):539-44. doi: 10.1038/nbt.2576. Epub 2013 Apr 21.
2
Comparison of three molecular assays for the detection and molecular characterization of circulating tumor cells in breast cancer.
Breast Cancer Res. 2013 Mar 7;15(2):R20. doi: 10.1186/bcr3395.
3
Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing.
Cancer Res. 2013 May 15;73(10):2965-75. doi: 10.1158/0008-5472.CAN-12-4140. Epub 2013 Mar 7.
4
Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition.
Science. 2013 Feb 1;339(6119):580-4. doi: 10.1126/science.1228522.
5
Genome-wide detection of single-nucleotide and copy-number variations of a single human cell.
Science. 2012 Dec 21;338(6114):1622-6. doi: 10.1126/science.1229164.
6
Circulating tumor cells: liquid biopsy of cancer.
Clin Chem. 2013 Jan;59(1):110-8. doi: 10.1373/clinchem.2012.194258. Epub 2012 Sep 26.
7
EMT and dissemination precede pancreatic tumor formation.
Cell. 2012 Jan 20;148(1-2):349-61. doi: 10.1016/j.cell.2011.11.025.
8
Circulating epithelial cells in patients with benign colon diseases.
Clin Chem. 2012 May;58(5):936-40. doi: 10.1373/clinchem.2011.175570. Epub 2011 Dec 28.
9
Prognostic value of HER2-positive circulating tumor cells in patients with metastatic breast cancer.
Int J Clin Oncol. 2012 Apr;17(2):96-104. doi: 10.1007/s10147-011-0260-0. Epub 2011 Jun 15.
10
A perspective on cancer cell metastasis.
Science. 2011 Mar 25;331(6024):1559-64. doi: 10.1126/science.1203543.
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