单细胞分辨率下的肿瘤异质性和转移。
Tumour heterogeneity and metastasis at single-cell resolution.
机构信息
Department of Physiology and Biophysics, University of California, Irvine, CA, USA.
Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA.
出版信息
Nat Cell Biol. 2018 Dec;20(12):1349-1360. doi: 10.1038/s41556-018-0236-7. Epub 2018 Nov 26.
Abstract
Tumours comprise a heterogeneous collection of cells with distinct genetic and phenotypic properties that can differentially promote progression, metastasis and drug resistance. Emerging single-cell technologies provide a new opportunity to profile individual cells within tumours and investigate what roles they play in these processes. This Review discusses key technological considerations for single-cell studies in cancer, new findings using single-cell technologies and critical open questions for future applications.
摘要
肿瘤由具有不同遗传和表型特性的异质性细胞组成，这些特性可以促进肿瘤的不同进展、转移和耐药。新兴的单细胞技术为研究肿瘤内单个细胞以及研究它们在这些过程中所起的作用提供了一个新的机会。这篇综述讨论了癌症中单细胞研究的关键技术考虑因素、使用单细胞技术的新发现以及未来应用的关键开放性问题。
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