The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Science. 2013 Sep 13;341(6151):1205-11. doi: 10.1126/science.1241146.
Immunological memory is the residuum of a successful immune response that in the B cell lineage comprises long-lived plasma cells and long-lived memory B cells. It is apparent that distinct classes of memory B cells exist, distinguishable by, among other things, immunoglobulin isotype, location, and passage through the germinal center. Some of this variation is due to the nature of the antigen, and some appears to be inherent to the process of forming memory. Here, we consider the heterogeneity in development and phenotype of memory B cells and whether particular functions are partitioned into distinct subsets. We consider also how understanding the details of generating memory may provide opportunities to develop better, functionally targeted vaccines.
免疫记忆是成功免疫应答的残余物，在 B 细胞谱系中包括长寿浆细胞和长寿记忆 B 细胞。显然，存在不同类型的记忆 B 细胞，可通过免疫球蛋白同种型、位置和通过生发中心的途径等因素来区分。这种变异的一部分归因于抗原的性质，而一部分似乎是形成记忆的过程所固有的。在这里，我们考虑记忆 B 细胞在发育和表型上的异质性，以及特定功能是否分配到不同的亚群中。我们还考虑了了解产生记忆的细节如何为开发更好的、功能靶向疫苗提供机会。
