B 细胞受体转基因小鼠作为研究记忆 B 细胞的工具。
B Cell Receptor Transgenic Mice as Tools to Study Memory B Cells.
机构信息
Department of Immunology, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
出版信息
Methods Mol Biol. 2024;2826:131-139. doi: 10.1007/978-1-0716-3950-4_10.
PMID:39017890
Abstract
B cell receptor (BCR) transgenic mice allow the control of the initial target (antigen) specificity of naïve B cells and to investigate their properties following activation. Here, I describe how BCR transgenic B cells can be used in combination with adoptive cell transfer and immunization models to study memory B cell formation and reactivation.
摘要
B 细胞受体（BCR）转基因小鼠可控制初始靶标（抗原）特异性的初始 B 细胞，并在激活后研究其特性。在这里，我将介绍如何将 BCR 转基因 B 细胞与过继细胞转移和免疫模型结合使用，以研究记忆 B 细胞的形成和再激活。
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