Davis M A, Neuhaus J M, Ettinger W H, Mueller W H
Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco 94143-0560.
Am J Epidemiol. 1990 Oct;132(4):701-7. doi: 10.1093/oxfordjournals.aje.a115711.
The association of body fat distribution with single and combined site osteoarthritis was investigated using data from the US Health Examination Survey I, 1960-1962 (HES I) and the first National Health and Nutrition Examination Survey I, 1971-1975 (NHANES I). The study included 1,636 adults aged 35-79 years from HES I with hands and feet radiographs and four anthropometric fat distribution measures--subscapular and triceps skinfolds, waist girth, and seat breadth--and 3,885 adults aged 45-74 from NHANES I with knee radiographs and subscapular and triceps skinfold measures. Sex-specific data, adjusted for age, race, and body mass index, were analyzed using polychotomous logistic regression. There was a positive association of body mass index with knee osteoarthritis and with combined hands and feet osteoarthritis. A peripheral body girth pattern was associated with combined site osteoarthritis of the hands and feet; however, there was no consistent pattern of association of body fat distribution with knee osteoarthritis nor with osteoarthritis of the hands or feet only. These findings suggest that the central body fat pattern observed in previous studies to be associated with cardiovascular and gallbladder disease, and with diabetes, is not associated with osteoarthritis of the hands, feet, or knees.
利用1960 - 1962年美国第一次健康检查调查（HES I）以及1971 - 1975年第一次全国健康与营养检查调查（NHANES I）的数据，研究了体脂分布与单部位及多部位骨关节炎之间的关联。该研究纳入了1636名年龄在35 - 79岁之间来自HES I的成年人，这些人有手部和足部的X光片以及四项人体测量的脂肪分布指标——肩胛下和肱三头肌皮褶厚度、腰围和臀宽，还纳入了3885名年龄在45 - 74岁之间来自NHANES I的成年人，这些人有膝部X光片以及肩胛下和肱三头肌皮褶厚度测量数据。使用多分类逻辑回归分析了按年龄、种族和体重指数调整后的性别特异性数据。体重指数与膝骨关节炎以及手部和足部合并骨关节炎呈正相关。外周体围模式与手部和足部的多部位骨关节炎相关；然而，体脂分布与膝骨关节炎以及仅手部或足部的骨关节炎之间没有一致的关联模式。这些发现表明，先前研究中观察到的与心血管疾病、胆囊疾病以及糖尿病相关的中心性体脂模式，与手部、足部或膝部的骨关节炎无关。
