Matera C, Warren W B, Moomjy M, Fink D J, Fox H E
Department of Obstetrics and Gynecology, Columbia University, College of Physicians and Surgeons, New York, NY.
Am J Obstet Gynecol. 1990 Sep;163(3):797-801. doi: 10.1016/0002-9378(90)91071-j.
Increasing use of cocaine among pregnant women has been reported. This study was conducted to determine the prevalence of positive urine toxicologic screens for cocaine and other substances of patients admitted to the Sloane Hospital for Women. Urine samples were obtained from 509 women admitted to the delivery suite. The overall prevalence of cocaine was 10% (n = 51). Cocaine use was 10 times more prevalent in the clinic population (14%) than in the private population, (1.4%). In addition, women whose urine samples were positive for cocaine were more likely to have no prenatal care, previous induced abortions, to be human immunodeficiency virus-positive, and admitted previous use of cigarettes, alcohol, cocaine, and other drugs. Amphetamines were detected in 13% (n = 65) of patients. However, the screens did not distinguish between metabolites of amphetamines and other drugs such as cold medications. The medical history alone predicted only 37% (n = 19) of the cocaine-positive screens and none of the amphetamine-positive screens.
据报道,孕妇中使用可卡因的情况日益增多。本研究旨在确定斯隆女子医院收治患者尿液毒理学筛查中可卡因及其他物质呈阳性的患病率。从509名入住产房的女性中采集了尿液样本。可卡因的总体患病率为10%(n = 51)。可卡因在门诊人群中的使用率(14%)是在自费人群中(1.4%)的10倍。此外,尿液样本可卡因呈阳性的女性更有可能未接受产前护理、有过人工流产史、感染人类免疫缺陷病毒,并且承认之前使用过香烟、酒精、可卡因及其他药物。13%(n = 65)的患者检测出苯丙胺。然而,筛查无法区分苯丙胺的代谢物与其他药物,如感冒药。仅根据病史只能预测出37%(n = 19)的可卡因阳性筛查结果,而无法预测任何苯丙胺阳性筛查结果。