Burroughs P, Dahners L E
Department of Surgery, University of North Carolina, Chapel Hill 27599-7055.
Am J Sports Med. 1990 Jul-Aug;18(4):376-8. doi: 10.1177/036354659001800407.
Previous studies have documented that mobilization ad libitum has a beneficial effect on the healing of ligaments as compared to immobilization. This study was undertaken to determine whether enforced exercise (over and above motion ad libitum) would have a further beneficial effect or, instead, an adverse effect on the healing of ligaments. Large male Sprague-Dawley rats with unrepaired transections of the medial collateral ligament were separated into five groups of similar mean weights. Two of these groups had the anterior cruciate ligament and the medial capsule transected in addition to the medial collateral ligament, rendering the knee unstable. The groups were then subjected to varying regimens of enforced exercise (swimming). After 12 days, the mechanical characteristics of the femur, medial collateral ligament, and tibia complex were evaluated. Rats with intact secondary valgus stabilizers (medial capsule and anterior cruciate ligament) that swam daily for either 5 (moderate) or 15 (near exhaustion) minutes were found to have increases in the tensile strength of the femur, medial collateral ligament, tibia complex as compared to rats that did not swim. Unstable knees (with transected secondary valgus stabilizers) did not show an increase in the tensile strength of the femur, medial collateral ligament, tibia complex when subjected to moderate increase in enforced exercise (swimming 5 minutes). The unstable groups were, however, significantly more lax than the groups that underwent identical exercise regimens but had intact secondary valgus stabilizers. Significant differences in the stiffness of the ligaments in the different groups were not detected.(ABSTRACT TRUNCATED AT 250 WORDS)
以往研究已证明，与固定相比，随意活动对韧带愈合具有有益作用。本研究旨在确定强制运动（超出随意活动的范围）对韧带愈合是否会有进一步的有益作用，还是会产生不利影响。将内侧副韧带未修复横断的大型雄性斯普拉格-道利大鼠分为五组，每组平均体重相似。其中两组除内侧副韧带横断外，还切断了前交叉韧带和内侧关节囊，使膝关节不稳定。然后对这些组施加不同的强制运动（游泳）方案。12天后，评估股骨、内侧副韧带和胫骨复合体的力学特性。与未游泳的大鼠相比，具有完整二级外翻稳定结构（内侧关节囊和前交叉韧带）且每天游泳5分钟（适度）或15分钟（接近疲劳）的大鼠，其股骨、内侧副韧带、胫骨复合体的拉伸强度有所增加。当进行适度的强制运动增加（游泳5分钟）时，不稳定膝关节（二级外翻稳定结构横断）的股骨、内侧副韧带、胫骨复合体的拉伸强度未显示增加。然而，不稳定组比接受相同运动方案但具有完整二级外翻稳定结构的组明显更松弛。不同组韧带刚度未检测到显著差异。（摘要截断于250字）
