Jaffe K M, McDonald C M, Ingman E, Haas J
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle.
Arch Phys Med Rehabil. 1990 Sep;71(10):742-4.
A case-control study was undertaken to see if symptoms of upper gastrointestinal (UGI) (oropharyngeal, esophageal, and gastric) dysfunction occurred more frequently in males afflicted with Duchenne muscular dystrophy (DMD) than healthy controls. Subjects included 55 children with confirmed DMD and 55 age-matched controls without neuromuscular disease. All subjects and/or their parents responded to a standard set of questions concerning the frequency of symptoms of UGI dysfunction. Responses of the DMD and control groups were compared using the Wilcoxon signed rank test. A significantly higher percentage of DMD patients experienced nasal quality to the voice, dysphagia, choking while eating, the need to clear the throat during or after eating, heartburn, and vomiting during or after meals, than did controls. Only one symptom--heartburn--was found significantly more frequently in the 33 nonambulatory than the 22 ambulatory DMD subjects. These findings document that feeding difficulty and symptoms consistent with oropharyngeal, esophageal, and gastric dysfunction are more frequent in the DMD population than healthy, age-matched controls.
开展了一项病例对照研究，以观察患有杜氏肌营养不良症（DMD）的男性上消化道（UGI）（口咽、食管和胃）功能障碍症状的发生频率是否高于健康对照。研究对象包括55名确诊为DMD的儿童和55名年龄匹配、无神经肌肉疾病的对照。所有研究对象和/或其父母都回答了一组关于UGI功能障碍症状发生频率的标准问题。使用Wilcoxon符号秩检验比较DMD组和对照组的回答。与对照组相比，DMD患者出现声音鼻音、吞咽困难、进食时呛噎、进食期间或之后需要清嗓、烧心以及进食期间或之后呕吐的比例明显更高。在33名非行走型DMD患者中，仅有一种症状——烧心——的发生频率显著高于22名行走型DMD患者。这些研究结果表明，与健康的年龄匹配对照相比，DMD人群中喂养困难以及与口咽、食管和胃功能障碍相符的症状更为常见。
