氯氮卓、中枢神经系统兴奋剂及其组合对小鼠回避行为的影响。
Effects of chlordiazepoxide, CNS stimulants and their combinations on avoidance behaviour in mice.
作者信息
Sansone M
出版信息
Arch Int Pharmacodyn Ther. 1975 Jun;215(2):190-6.
PMID:240332
Abstract
Various central stimulant drugs were tested in mice subjected to five daily 100-trial avoidance sessions in the shuttle-box. Facilitation of avoidance responding was observed following i.p. administration of metamphetamine and cocaine, but not following methlyphenidate, caffeine, pentetrazole and strychnine. Some favourable effects were obtained by combining the above stimulant drugs with cholrdiazepoxide. Advantages in the combination with chlordiazepoxide were particularly evident in the case of methamphetamine.
摘要
在穿梭箱中对小鼠进行为期五天、每天100次试验的回避训练，期间测试了多种中枢兴奋剂药物。腹腔注射甲基苯丙胺和可卡因后观察到回避反应得到促进，但哌甲酯、咖啡因、戊四氮和士的宁则未观察到这种促进作用。将上述兴奋剂药物与氯氮卓联合使用取得了一些有利效果。甲基苯丙胺与氯氮卓联合使用时的优势尤为明显。
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