1 Department of Cell Biology and Chemical Physiology, The Scripps Research Institute, La Jolla, California.
Am J Respir Crit Care Med. 2014 Jan 1;189(1):96-103. doi: 10.1164/rccm.201306-1164WS.
Recent discoveries indicate that disorders of protein folding and degradation play a particularly important role in the development of lung diseases and their associated complications. The overarching purpose of the National Heart, Lung, and Blood Institute workshop on "Malformed Protein Structure and Proteostasis in Lung Diseases" was to identify mechanistic and clinical research opportunities indicated by these recent discoveries in proteostasis science that will advance our molecular understanding of lung pathobiology and facilitate the development of new diagnostic and therapeutic strategies for the prevention and treatment of lung disease. The workshop's discussion focused on identifying gaps in scientific knowledge with respect to proteostasis and lung disease, discussing new research advances and opportunities in protein folding science, and highlighting novel technologies with potential therapeutic applications for diagnosis and treatment.
最近的发现表明，蛋白质折叠和降解的紊乱在肺部疾病及其相关并发症的发展中起着特别重要的作用。美国国立心肺血液研究所关于“肺部疾病中畸形蛋白质结构和蛋白质平衡”的研讨会的首要目的是确定这些蛋白质平衡科学新发现所显示的机制和临床研究机会，这些机会将促进我们对肺部病理生物学的分子理解，并为预防和治疗肺部疾病的新诊断和治疗策略提供便利。研讨会的讨论重点是确定蛋白质平衡和肺部疾病方面的科学知识差距，讨论蛋白质折叠科学的新研究进展和机会，并强调具有潜在治疗应用的新型诊断和治疗技术。
