Aicardi J, Chevrie J J
Arch Fr Pediatr. 1975 Apr;32(4):309-17.
Twenty cases of acute neurological complications occuring within 7 days of pertussis immunization are reported. Convulsions were present in every case and status epilepticus was observed in five infants. In only 4 cases were neurological or epileptic sequelae lacking. The clustering of neurological complications in the 24 hours following immunization is not consistent with the hypothesis of a mere temporal coincidence. However, the mechanism and incidence of post-immunization encephalopathies remains obscure and epidemiological studies are in order.
报告了20例在百日咳免疫接种7天内发生急性神经并发症的病例。所有病例均出现惊厥,5名婴儿出现癫痫持续状态。只有4例没有神经或癫痫后遗症。免疫接种后24小时内神经并发症的聚集情况与单纯时间巧合的假设不一致。然而,免疫接种后脑病的机制和发病率仍不清楚,因此需要进行流行病学研究。